ArticleBMJ open diabetes research & care2022
Alterations in plantar vessel blood flow in patients with mild diabetic peripheral neuropathy.
Article in BMJ open diabetes research & care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 8 citations in OpenAlex.
- A case description of non-invasive plantar foot perfusion assessment pre-and post-angioplasty in patients with peripheral arterial disease using spatial frequency domain imaging.Quantitative imaging in medicine and surgery · 2026Article
- Prevalence of DSPN and Its Risk Factors Among Type 2 Diabetes Patients Attending Xuhang Community Health Service Center, in Shanghai, China.International journal of endocrinology · 2026Article
- Methods for tissue perfusion assessment after Dellon decompression of tarsal tunnels in diabetic neuropathy: key to effective management-a narrative review.Quantitative imaging in medicine and surgery · 2025Review
- Investigating the Effectiveness of Electroacupuncture for Diabetic Peripheral Neuropathy and Exploring the Feasibility of Infrared Thermography as an Efficacy Assessment Tool: Study Protocol for a Randomized Controlled Trial.Journal of pain research · 2024Article
- Relationship of PIEZO1 and PIEZO2 vascular expression with diabetic neuropathy.Frontiers in physiology · 2023Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEarly identification and treatment of diabetic peripheral neuropathy (DPN) are crucial. Presently, the mechanism of DPN is not very clear, and there are inconclusive conclusions about the influencing factors of vascular dynamic characteristics in DPN. This study aims to detect and compare the hemodynamic characteristics of plantar blood vessels in patients with mild DPN and healthy participants to explore a simple and reliable new idea and a potential method for early assessment of DPN and to investigate the influence of gender and age on hemodynamic characteristics. RESEARCH DESIGN AND
methodsSixty age-matched and gender-matched patients with mild DPN (30 men and 30 women) and 60 healthy participants were randomly recruited. Color Doppler ultrasound was used to measure and analyze the hemodynamic characteristics of plantar-related vessels.
resultsUltrasonic measurements had good test-retest reliability. There may be no statistically significant differences in the blood flow velocity and blood flow in the plantar-related blood vessels of participants, irrespective of their gender and age. For patients with mild DPN, color Doppler ultrasound may indicate early hemodynamic abnormalities when there are no obvious abnormalities in the large arteries of the lower limbs, which are specifically manifested as increased blood flow velocity and blood flow in the distal small vessels.
conclusionsOur study provides in vivo data support for the dynamic characteristics of the plantar blood vessel biomechanical model and provides a new idea of in vivo and non-invasive early diagnosis of DPN.
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