Trial reportBritish journal of anaesthesia2023
Apnoeic oxygenation in morbid obesity: a randomised controlled trial comparing facemask and high-flow nasal oxygen delivery.
Trial report in British journal of anaesthesia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03428256 (A Randomised Controlled Comparison of Effectiveness of Facemask Preoxygenation and Transnasal Humidified Rapid-Insufflation Ventilatory Exchange), which is not on this map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomised Controlled Comparison of Effectiveness of Facemask Preoxygenation and Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) in Bariatric Patients Undergoing General Anaesthesia
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Guideline
- Oxygenation during the apnoeic phase preceding intubation in adults in prehospital, emergency department, intensive care and operating theatre environments.The Cochrane database of systematic reviews · 2023Pooled it
- Efficacy of High-Flow Nasal Cannula versus Conventional Oxygen Therapy in Obese Patients during the Perioperative Period: A Systematic Review and Meta-Analysis.Canadian respiratory journal · 2022Pooled it
- Use of optiflow THRIVE high-flow nasal oxygen system versus a non-rebreather oxygen delivery device in patients with increased risk of airway obstruction in interventional radiology procedures: a randomized pilot study.BMC anesthesiology · 2026Trial
- Comparison of high-flow nasal oxygenation and standard low-flow nasal oxygenation during rigid bronchoscopy: a randomized controlled trial.Korean journal of anesthesiology · 2025Trial
- High-Flow Nasal Oxygen Prolongs Safe Apnea Time in Obstructive Sleep Apnea Patients Undergoing General Anesthesia: A Randomized Controlled Trial.Risk management and healthcare policy · 2025Trial
- Use of high-flow nasal oxygenation in minimizing the occurrence of hypotension during induction of anesthesia with remimazolam in elderly patients.Journal of anesthesia · 2026Article
- Personalizing Peri-Intubation Oxygenation in Patients at Risk of Acute Hypoxemic Respiratory Failure: A Phenotype-Driven Narrative Review of High-Flow Nasal Oxygen and Non-Invasive Ventilation.Journal of personalized medicine · 2026Review
- High-flow nasal oxygen in the perioperative period: Enough evidence, or questions still unanswered?Indian journal of anaesthesia · 2026Article
- Apnoeic oxygenation with high-flow nasal oxygen in adult patients undergoing endoscopic pharyngolaryngeal surgery: a clinical review.European journal of anaesthesiology and intensive care · 2026Review
- High-Flow Nasal Oxygen in Contemporary Airway Management: Enhancing Physiological Safety in Anaesthesia-A Narrative Review.Healthcare (Basel, Switzerland) · 2026Review
- Article
- High-flow nasal cannulaERJ open research · 2026Article
- High-Flow Nasal Cannula Oxygen Therapy in Perioperative Respiratory Care: Application and Prospects.Journal of multidisciplinary healthcare · 2026Review
- Efficacy of high-flow nasal cannula in improving the view of the glottis during flexible bronchoscopy for tracheal intubation.British journal of anaesthesia · 2025Article
- All India Difficult Airway Association 2025 Guidelines for the management of unanticipated difficult airway in adults under general anaesthesia.Indian journal of anaesthesia · 2025Article
- High-flow oxygenation therapy for a sedated elderly frail patient with hiccups undergoing transcatheter aortic valve implantation.JA clinical reports · 2025Article
- Apneic oxygenation with Transnasal Humidified Rapid-insufflation Ventilator Exchange (THRIVE) in obstructive sleep apnea patients: study protocol of a randomized controlled trial.BMC anesthesiology · 2025Article
- High-flow nasal cannula oxygenation reduces desaturation risk during diagnostic flexible bronchoscopy under deep sedation: a randomized controlled trial.Frontiers in medicine · 2025Article
- Screening and Perioperative Management of Obesity Hypoventilation Syndrome.Journal of clinical medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity is a risk factor for airway-related incidents during anaesthesia. High-flow nasal oxygen has been advocated to improve safety in high-risk groups, but its effectiveness in the obese population is uncertain. This study compared the effect of high-flow nasal oxygen and low-flow facemask oxygen delivery on duration of apnoea in morbidly obese patients.
methodsMorbidly obese patients undergoing bariatric surgery were randomly allocated to receive either high-flow nasal (70 L min
resultsEighty patients were studied (41 High-Flow Nasal Oxygen, 39 Facemask). The median apnoea time was 18 min in both the High-Flow Nasal Oxygen (IQR 18-18 min) and the Facemask (inter-quartile range [IQR], 4.1-18 min) groups. Five patients in the High-Flow Nasal Oxygen group and 14 patients in the Facemask group desaturated to 92% within 18 min. The risk of desaturation was significantly lower in the High-Flow Nasal Oxygen group (hazard ratio=0.27; 95% confidence interval [CI], 0.11-0.65; P=0.007).
conclusionsIn experienced hands, apnoeic oxygenation is possible in morbidly obese patients, and oxygen desaturation did not occur for 18 min in the majority of patients, whether oxygen delivery was high-flow nasal or low-flow facemask. High-flow nasal oxygen may reduce desaturation risk compared with facemask oxygen. Desaturation risk is a more clinically relevant outcome than duration of apnoea. Individual physiological factors are likely to be the primary determinant of risk rather than method of oxygen delivery. CLINICAL
trial registrationNCT03428256.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.