ArticleBiological psychiatry2022
Mapping Complex Brain Torque Components and Their Genetic Architecture and Phenomic Associations in 24,112 Individuals.
Article in Biological psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Variations of global brain asymmetry are associated with aging and related diseases.Science advances · 2026Article
- A decade of discovery: Leveraging genomic data in the ABCD study to illuminate adolescent neurodevelopment.Developmental cognitive neuroscience · 2026Review
- Structural and functional brain asymmetry in relation to heterogeneous causes of situs inversus totalis.Brain structure & function · 2026Article
- On handedness and the lateralization of fusiform face area(s).Brain structure & function · 2025Article
- Looking at Both Sides: Integrating Data From Both Hemispheres Is Crucial in Rodent Neuroscience.The European journal of neuroscience · 2025Review
- Longitudinal changes in brain asymmetry track lifestyle and disease.Nature communications · 2025Article
- A Neural Network Approach to Identify Left-Right Orientation of Anatomical Brain MRI.Brain and behavior · 2025Article
- Brain (Yakovlevian) torque direction is associated with volume asymmetry of the intracranial transverse sinuses: evidence from situs inversus totalis.Brain structure & function · 2024Article
- The uniqueness of the human brain: a review.Dementia & neuropsychologia · 2024Review
- A multiscale characterization of cortical shape asymmetries in early psychosis.Brain communications · 2024Article
- Approaches to Measuring Language Lateralisation: An Exploratory Study Comparing Two fMRI Methods and Functional Transcranial Doppler Ultrasound.Neurobiology of language (Cambridge, Mass.) · 2024Article
- Evolution of Human Brain Left-Right Asymmetry: Old Genes with New Functions.Molecular biology and evolution · 2023Article
- Tracing the development and lifespan change of population-level structural asymmetry in the cerebral cortex.eLife · 2023Article
- Dissociable brain structural asymmetry patterns reveal unique phenome-wide profiles.Nature human behaviour · 2023Article
- A brief sketch across multiscale and comparative neuroanatomical features.Frontiers in neuroanatomy · 2023Article
- Article
- Yakovlevian Torque: Something Old and Something New.Biological psychiatry · 2022Article
- The Internal Cranial Anatomy of a Female With Endocrine Disorders From a Mediaeval Population.Frontiers in endocrinology · 2022Article
Corrections and comments
- Commented on by
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe functional significance and mechanisms determining the development and individual variability of structural brain asymmetry remain unclear. Here, we systematically analyzed all relevant components of the most prominent structural asymmetry, brain torque (BT), and their relationships with potential genetic and nongenetic modifiers in a sample comprising 24,112 individuals from six cohorts.
methodsBT features, including petalia, bending, dorsoventral shift, brain tissue distribution asymmetries, and cortical surface positional asymmetries, were directly modeled using a set of automatic three-dimensional brain shape analysis approaches. Age-, sex-, and handedness-related effects on BT were assessed. The genetic architecture and phenomic associations of BT were investigated using genome- and phenome-wide association scans.
resultsOur results confirmed the population-level predominance of the typical counterclockwise torque and suggested a first attenuating, then enlarging dynamic across the life span (3-81 years) primarily for frontal, occipital, and perisylvian BT features. Sex/handedness, BT, and cognitive function of verbal-numerical reasoning were found to be interrelated statistically. We observed differential heritability of up to 56% for BT, especially in temporal language areas. Individual variations of BT were also associated with various phenotypic variables of neuroanatomy, cognition, lifestyle, sociodemographics, anthropometry, physical health, and adult and child mental health. Our genomic analyses identified a number of genetic associations at lenient significance levels, which need to be further validated using larger samples in the future.
conclusionsThis study provides a comprehensive description of BT and insights into biological and other factors that may contribute to the development and individual variations of BT.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.