Evidence map›Paper›PMID 35027080›Full record

ReviewEuropean journal of medical research2022

Potential therapeutic options for COVID-19: an update on current evidence.

Zahra Niknam, Ameneh Jafari, Ali Golchin, Fahima Danesh Pouya, Mohadeseh Nemati, Mostafa Rezaei-Tavirani, Yousef Rasmi

Open access · goldAbstract readReview
In one paragraph

Review in European journal of medical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 1 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Remdesivir in COVID-19: pros and cons.Frontiers in pharmacology · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. Anti-interferon armamentarium of human coronaviruses.Cellular and molecular life sciences : CMLS · 2025
    Review
  11. Review
  12. Single-cell Technology in Stem Cell Research.Current stem cell research & therapy · 2025
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Heliyon · 2024
    Review
  19. Article
  20. Review

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Zahra Niknam *Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ameneh Jafari *Advanced Therapy Medicinal Product (ATMP) Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
Ali GolchinDepartment of Clinical Biochemistry and Applied Cell Sciences, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Fahima Danesh PouyaDepartment of Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Mohadeseh NematiDepartment of Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Mostafa Rezaei-TaviraniProteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. tavirany@yahoo.com.ORCID http://orcid.org/0000-0003-1767-7475
Yousef RasmiDepartment of Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran. yrasmi@gmail.com.
Urmia University · IRShahid Beheshti University of Medical Sciences · IRAcademic Center for Education, Culture and Research · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2, a novel coronavirus, is the agent responsible for the COVID-19 pandemic and is a major public health concern nowadays. The rapid and global spread of this coronavirus leads to an increase in hospitalizations and thousands of deaths in many countries. To date, great efforts have been made worldwide for the efficient management of this crisis, but there is still no effective and specific treatment for COVID-19. The primary therapies to treat the disease are antivirals, anti-inflammatories and respiratory therapy. In addition, antibody therapies currently have been a many active and essential part of SARS-CoV-2 infection treatment. Ongoing trials are proposed different therapeutic options including various drugs, convalescent plasma therapy, monoclonal antibodies, immunoglobulin therapy, and cell therapy. The present study summarized current evidence of these therapeutic approaches to assess their efficacy and safety for COVID-19 treatment. We tried to provide comprehensive information about the available potential therapeutic approaches against COVID-19 to support researchers and physicians in any current and future progress in treating COVID-19 patients.

Indexed as

COVID-19 Drug TreatmentImmunization, PassiveAntibodies, MonoclonalAntibodies, NeutralizingAntiviral AgentsClinical Trials as TopicCOVID-19COVID-19 SerotherapyDietary SupplementsHumansImmunoglobulins, IntravenousPandemicsSARS-CoV-2Treatment OutcomeAntibodies, MonoclonalAntibodies, NeutralizingAntiviral AgentsImmunoglobulins, IntravenousCell therapyConvalescent plasmaCOVID-19ImmunoglobulinsMonoclonal antibodiesRepurposed drugs

Identifiers

PMID35027080
PMCPMC8755901
OpenAlexW4206594482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.