Evidence map›Paper›PMID 35027069›Full record

ArticleBMC complementary medicine and therapies2022

The effect of Kappaphycus alvarezii active fraction on oxidative stress and inflammation in streptozotocin and nicotinamide-induced diabetic rats.

Evy Yulianti, Sunarti, Mae Sri Hartati Wahyuningsih

Open access · goldAbstract read
In one paragraph

Article in BMC complementary medicine and therapies, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Evy YuliantiDepartment of Biology Education, Faculty of Mathematics and Science, Universitas Negeri Yogyakarta, Yogyakarta, Indonesia.
SunartiDepartment of Biochemistry, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Mae Sri Hartati WahyuningsihDepartment of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. maeshw@ugm.ac.id.ORCID http://orcid.org/0000-0002-9274-5573
Universitas Gadjah Mada · IDYogyakarta State University · ID

Funding

ministry of finance education fund management institution (lpdp) KET-1467/LPDP.3/2018
6 · The paper itself

Abstract

backgroundHigh glucose concentration increases the glycation process which leads to oxidative stress and inflammation, that can cause complications in diabetes. Several medicinal plants have been used in the treatment of diabetes and its complications. One of them is Kappaphycus alvarezii, an algae that has known antidiabetic abilities. This study aimed to examine the effect of K. alvarezii active fraction on plasma hydrogen peroxide (H

methodsActive fraction was obtained from bioassay-guided fractionation with antiglycation ability. In vivo study was performed on twenty Wistar male rats. The level of H

resultsActive fraction significantly reduced plasma H

conclusionsK. alvarezii active fraction has an activity to reduce plasma H

Indexed as

PhytotherapyRhodophytaAnimalsDiabetes Mellitus, ExperimentalGene ExpressionHydrogen PeroxideInflammationMaleNADPH Oxidase 4NF-kappa BOxidative StressPlant PreparationsRatsTumor Necrosis Factor-alphaHydrogen PeroxideNADPH Oxidase 4NF-kappa BNox4 protein, ratPlant PreparationsTumor Necrosis Factor-alphaDiabetesH2O2K. alvareziiNFκBNOX4TNFα

Identifiers

PMID35027069
PMCPMC8759202
OpenAlexW4205846133

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.