Evidence map›Paper›PMID 35027053›Full record

ArticleJournal of ovarian research2022

MicroRNA-625-3p improved proliferation and involved chemotherapy resistance via targeting PTEN in high grade ovarian serous carcinoma.

Lili Zhong, Xiumin Liu, Lixing Wang, Yu Liu, Duohan Zhang, Yinlong Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lili ZhongThe Second Hospital of Jilin University, Changchun, 130041, China.
Xiumin LiuClinical Laboratory, Second Hospital of Jilin University, Changchun, 130041, China.
Lixing WangDepartment of Nuclear Medicine, The Second Hospital of Jilin University, No. 218, Ziqiang Street, Nanguan, Changchun, 130041, Jilin, People's Republic of China.
Yu LiuDepartment of Nuclear Medicine, The Second Hospital of Jilin University, No. 218, Ziqiang Street, Nanguan, Changchun, 130041, Jilin, People's Republic of China.
Duohan ZhangDepartment of Nuclear Medicine, The Second Hospital of Jilin University, No. 218, Ziqiang Street, Nanguan, Changchun, 130041, Jilin, People's Republic of China.
Yinlong ZhaoDepartment of Nuclear Medicine, The Second Hospital of Jilin University, No. 218, Ziqiang Street, Nanguan, Changchun, 130041, Jilin, People's Republic of China. yinlongzhao@aol.com.
Second Affiliated Hospital of Jilin University · CN

Funding

bethune project 419161900018department of finance of jilin province 3D518V613429special health project of jilin province 2020SCZT061special project of medical and health personnel in jilin province 2019SCZT026
6 · The paper itself

Abstract

objectiveHigh-grade serous ovarian cancer (HGSOC) is an aggressive gynaecological malignancy and associated with poor prognosis. Here we examined the effects of miR-625-3p on proliferation, treatment, migration and invasion in HGSOC.

methodsThe proliferation of HGSOC cells was evaluated by MTT assay. Transwell assay was performed to examine migration and matrigel assay were used to assess invasion. The effect of miR-625-3p on cisplatin-induced apoptosis was investigated by Caspase-Glo3/7 assay. The dual-luciferase reporter assay was carried out to confirm the potential binding site.

resultsOverexpression of miR-625-3p promoted proliferation, and increased migration and invasion in HGSOC cells. MiR-625-3p significantly inhibited cisplatin sensitivity in HGSOC cells. Meanwhile, miR-625-3p decreased cisplatin-induced apoptosis by regulation of BAX and Bcl-2 expression. Furthermore, aberrant expression of miR-625-3p changed PTEN expression by directly binding to 3'UTR of PTEN. Further study showed miR-625-3p expression was higher in human HGSOC tissue than normal ovarian tissues and associated with higher clinical stage.

conclusionsmiR-625-3p promotes HGSOC growth, involves chemotherapy resistance and might serve as a potential biomarker to predict chemotherapy response and prognosis in HGSOC.

Indexed as

3' Untranslated RegionsApoptosisCell Line, TumorCell MovementCell ProliferationCisplatinCystadenocarcinoma, SerousDrug Resistance, NeoplasmFemaleGene Expression Regulation, NeoplasticHumansMicroRNAsOvarian NeoplasmsPTEN Phosphohydrolase3' Untranslated RegionsCisplatinMicroRNAsMIRN625 microRNA, humanPTEN PhosphohydrolasePTEN protein, humanApoptosisHGSOCmiR-625-3pPTEN

Identifiers

PMID35027053
PMCPMC8759160
OpenAlexW4206245435

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.