Trial reportBMC musculoskeletal disorders2022
An anti-inflammatory diet intervention for knee osteoarthritis: a feasibility study.
Trial report in BMC musculoskeletal disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- The effectiveness of dietary intervention in osteoarthritis management: a systematic review and meta-analysis of randomized clinical trials.European journal of clinical nutrition · 2025Pooled it
- The Effectiveness of Intermittent Fasting, Time Restricted Feeding, Caloric Restriction, a Ketogenic Diet and the Mediterranean Diet as Part of the Treatment Plan to Improve Health and Chronic Musculoskeletal Pain: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Targeted Microbial Shifts and Metabolite Profiles Were Associated with Clinical Response to an Anti-Inflammatory Diet in Osteoarthritis.Nutrients · 2025Trial
- Trial
- A mobile intervention to reduce pain and improve health-III: protocol for a remotely delivered randomized controlled trial of physical activity for pain management in older adults with obesity and knee or hip osteoarthritis.Frontiers in digital health · 2026Article
- From mechanical triggering to metabolic-inflammatory driving: a new paradigm of knee osteoarthritis pathogenesis.Frontiers in immunology · 2026Review
- A Pilot Randomized Control Trial Evaluating the Feasibility of a 12-Week Mediterranean Diet Intervention Without Caloric Restriction in Women with Polycystic Ovary Syndrome.Journal of clinical medicine · 2025Article
- Association Between Ultraprocessed Food Intake and Self-Reported Arthritis.American journal of preventive medicine · 2025Article
- Ketogenic Diet-Associated Worsening of Osteoarthritis Histologic Secerity, Increased Pain Sensitivity and Gut Microbiome Dysbiosis in Mice.ACR open rheumatology · 2025Article
- Patellofemoral Pain is a Multifactorial Complex Condition; Are We Missing a Multidisciplinary Approach to its Management? Time for a Paradigm Shift.Open access journal of sports medicine · 2025Review
- Effect of anti-inflammatory diets on health-related quality of life in adults with chronic disease: a systematic review and meta-analysis.BMJ nutrition, prevention & health · 2025Article
- The Interplay of Aging and PANoptosis in Osteoarthritis Pathogenesis: Implications for Novel Therapeutic Strategies.Journal of inflammation research · 2025Review
- Effects of Fasting on THP1 Macrophage Metabolism and Inflammatory Profile.International journal of molecular sciences · 2024Article
- Longitudinal changes in adiposity following anterior cruciate ligament reconstruction and associations with knee symptoms and function.Osteoarthritis and cartilage open · 2024Article
- Effectiveness of an anti-inflammatory diet versus low-fat diet for knee osteoarthritis: the FEAST randomised controlled trial protocol.BMJ open · 2024Article
- Article
- [Dietary inflammatory index related to knee osteoarthritis symptomatology].Revista medica del Instituto Mexicano del Seguro Social · 2024Observational
- Editorial: Diet, nutrition, and functional foods for chronic pain.Frontiers in nutrition · 2024Article
- The Knee-SCHOOL: a brief patient-centered multidisciplinary educational program for knee osteoarthritis.Frontiers in medicine · 2024Article
- Behaviour Change Techniques Used in Mediterranean Diet Interventions for Older Adults: A Systematic Scoping Review.Nutrients · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKnee osteoarthritis has an inflammatory component that is linked to pain and joint pathology, yet common non-surgical and non-pharmacological interventions (e.g., exercise, calorie restricting diets) do not typically target inflammation. We aimed to evaluate the feasibility of a telehealth delivered anti-inflammatory diet intervention for knee osteoarthritis.
methodsThis 9-week single-arm feasibility study recruited participants aged 40-85 years with symptomatic knee osteoarthritis (inclusion criteria: average pain ≥4/10 or maximal pain ≥5/10 during past week). All participants received a telehealth-delivered anti-inflammatory dietary education intervention involving 1:1 consultations at baseline, 3- and 6-week follow-up. The diet emphasised nutrient-dense wholefoods and minimally processed anti-inflammatory foods and discouraged processed foods considered to be pro-inflammatory. The primary outcome of feasibility was assessed via: i) eligibility, recruitment and retention rates; ii) self-reported dietary adherence; iii) adverse events; and iv) treatment satisfaction. Post-intervention interviews evaluated the acceptability of the dietary intervention delivered via telehealth. Secondary outcomes included changes in self-reported body mass, Knee injury and Osteoarthritis Outcome Score (KOOS), health-related quality of life (EuroQoL-5D), analgesic use and global rating of change. Worthwhile effects were determined by the minimal detectable change (MDC) for all five KOOS-subscales (pain, symptoms, activities of daily living, sport/recreation, quality of life) being contained within the 95% confidence interval.
resultsForty-eight of seventy-three (66%) individuals screened were eligible and 28 enrolled over 2 months (82% female, mean age 66 ± 8 years, body mass index 30.7 ± 4.8 kg.m
conclusionThis study supports the feasibility of a full-scale randomised controlled trial to determine the efficacy of a primarily telehealth-delivered anti-inflammatory dietary education intervention in adults with symptomatic knee osteoarthritis.
trial registrationACTRN12620000229976 prospectively on 25/2/2020.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.