Evidence map›Paper›PMID 35026987›Full record

Trial reportBMC infectious diseases2022

Effect of maternal vitamin D supplementation on nasal pneumococcal acquisition, carriage dynamics and carriage density in infants in Dhaka, Bangladesh.

Mahgol Taghivand, Lisa G Pell, Mohammed Z Rahman, Abdullah A Mahmud, Eric O Ohuma, Eleanor M Pullangyeum, Tahmeed Ahmed, Davidson H Hamer, Stanley H Zlotkin, Jonathan B Gubbay and 2 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02388516 (Maternal Vitamin D for Acute Respiratory Infections in Infancy), which is not on this map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02388516 phase3completednot on this map

Maternal Vitamin D for Acute Respiratory Infections in Infancy (MDARI): a Nested Sub-study in a Randomized Controlled Trial of Vitamin D Supplementation During Pregnancy and Lactation in Dhaka, Bangladesh

TypeinterventionalSponsorThe Hospital for Sick ChildrenRan2014 to 2016Enrolled1,214ConditionsUpper Respiratory Tract Infections, Lower Respiratory Tract InfectionsArmsVitamin D3, Placebo
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Mahgol TaghivandDepartment of Nutritional Sciences, University of Toronto, Toronto, Canada.
Lisa G PellCentre for Global Child Health & Child Health Evaluative Sciences, Hospital for Sick Children, 686 Bay Street, Toronto, ON, Canada.
Mohammed Z RahmanInfections Diseases Division & Nutrition and Clinical Services Division, icddr,b, Dhaka, Bangladesh.
Abdullah A MahmudInfections Diseases Division & Nutrition and Clinical Services Division, icddr,b, Dhaka, Bangladesh.
Eric O OhumaCentre for Global Child Health & Child Health Evaluative Sciences, Hospital for Sick Children, 686 Bay Street, Toronto, ON, Canada.
Eleanor M PullangyeumCentre for Global Child Health & Child Health Evaluative Sciences, Hospital for Sick Children, 686 Bay Street, Toronto, ON, Canada.
Tahmeed AhmedInfections Diseases Division & Nutrition and Clinical Services Division, icddr,b, Dhaka, Bangladesh.
Davidson H HamerDepartment of Global Health, Boston University School of Public Health, Boston, USA.
Stanley H ZlotkinDepartment of Nutritional Sciences, University of Toronto, Toronto, Canada.
Jonathan B GubbayDepartment of Pediatrics, Hospital for Sick Children & University of Toronto, 686 Bay Street, Toronto, ON, Canada.
Shaun K Morris *Centre for Global Child Health & Child Health Evaluative Sciences, Hospital for Sick Children, 686 Bay Street, Toronto, ON, Canada.
Daniel E Roth *Department of Nutritional Sciences, University of Toronto, Toronto, Canada. daniel.roth@sickkids.ca.
University of Toronto · CAInternational Centre for Diarrhoeal Disease Research · BDPublic Health Ontario · CABoston University · USHospital for Sick Children · CASickKids Foundation · CA

Funding

Bill and Melinda Gates Foundation OPP1066764
6 · The paper itself

Abstract

backgroundInvasive pneumococcal disease is a major cause of infant morbidity and death worldwide. Vitamin D promotes anti-pneumococcal immune responses in vitro, but whether improvements in infant vitamin D status modify risks of nasal pneumococcal acquisition in early life is not known.

methodsThis is a secondary analysis of data collected in a trial cohort in Dhaka, Bangladesh. Acute respiratory infection (ARI) surveillance was conducted from 0 to 6 months of age among 1060 infants of women randomized to one of four pre/post-partum vitamin D dose combinations or placebo. Nasal swab samples were collected based on standardized ARI criteria, and pneumococcal DNA quantified by qPCR. Hazards ratios of pneumococcal acquisition and carriage dynamics were estimated using interval-censored survival and multi-state modelling.

resultsPneumococcal carriage was detected at least once in 90% of infants by 6 months of age; overall, 69% of swabs were positive (2616/3792). There were no differences between any vitamin D group and placebo in the hazards of pneumococcal acquisition, carriage dynamics, or carriage density (p > 0.05 for all comparisons).

conclusionDespite in vitro data suggesting that vitamin D promoted immune responses against pneumococcus, improvements in postnatal vitamin D status did not reduce the rate, alter age of onset, or change dynamics of nasal pneumococcal colonization in early infancy. Trial registration Registered in ClinicalTrials.gov with the registration number of NCT02388516 and first posted on March 17, 2015.

Indexed as

Pneumococcal InfectionsStreptococcus pneumoniaeBangladeshCarrier StateDietary SupplementsFemaleHumansInfantNasopharynxPneumococcal VaccinesVitamin DVitaminsPneumococcal VaccinesVitamin DVitaminsBangladeshInfantsMaternal supplementationPneumococcal carriageVitamin D

Identifiers

PMID35026987
PMCPMC8759256
OpenAlexW4206156708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.