Evidence map›Paper›PMID 35026950›Full record

ArticleACS infectious diseases2022

Nipah Virus V Protein Binding Alters MDA5 Helicase Folding Dynamics.

Nicole D Wagner, Hejun Liu, Henry W Rohrs, Gaya K Amarasinghe, Michael L Gross, Daisy W Leung

Open access · bronzeAbstract read
In one paragraph

Article in ACS infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Nipah virus: a summary for clinicians.International journal of emergency medicine · 2025
    Review
  4. Review
  5. Article
  6. Molecular determinants of cross-species transmission in emerging viral infections.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nicole D WagnerDivision of Infectious Diseases, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0003-3980-4893
Hejun LiuDivision of Infectious Diseases, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Henry W RohrsDepartment of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130, United States.
Gaya K AmarasingheDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0002-0418-9707
Michael L GrossDepartment of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130, United States.ORCID 0000-0003-1159-4636
Daisy W LeungDivision of Infectious Diseases, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0002-7189-9557
Washington University in St. Louis · US

Funding

Virology BSL4 CoreP01AI120943 · NIAID · WASHINGTON UNIVERSITY · PI Gaya K. Amarasinghe · 2016 to 2026
$30.2M
TrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0M
Molecular mechanisms of immune dysregulation by filoviral interferon U19AI109945 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BASLER, CHRISTOPHER F · 2014 to 2018
$9.5M
Mechanisms of actin cytoskeleton modulation by PneumovirusesR01AI140758 · NIAID · UNIVERSITY OF KENTUCKY · PI DUTCH, REBECCA E., LEUNG, DAISY W · 2018 to 2022
$3.3M
A Biomedical Mass Spectrometry Resource: Ongoing Driving Biomedical ProjectsR24GM136766 · NIGMS · WASHINGTON UNIVERSITY · PI GROSS, MICHAEL L · 2020 to 2022
$2.3M
NIAID NIH HHS P01 AI120943NIAID NIH HHS R01 AI140758NIAID NIH HHS U19 AI109945NIGMS NIH HHS P41 GM103422NIGMS NIH HHS R24 GM136766
6 · The paper itself

Abstract

Nipah virus (NiV) is an emerging and deadly zoonotic paramyxovirus that is responsible for periodic epidemics of acute respiratory illness and encephalitis in humans. Previous studies have shown that the NiV V protein antagonizes host antiviral immunity, but the molecular mechanism is incompletely understood. To address this gap, we biochemically characterized NiV V binding to the host pattern recognition receptor MDA5. We find that the C-terminal domain of NiV V (V

Indexed as

Nipah VirusHumansProtein BindingVirus Attachmenthydrogen−deuterium exchange mass spectrometryIFN antagonistMDA5Nipah virusV protein

Identifiers

PMID35026950
PMCPMC8762660
OpenAlexW4200479167

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.