ArticleNursing research
Longitudinal Analysis of Sleep Disturbance in Breast Cancer Survivors.
Article in Nursing research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The impact of breast cancer treatment on sleep disturbance: a systematic review.Breast cancer research and treatment · 2025Pooled it
- Chinese Medicines Treatment for Sleep Disturbance in Breast Cancer Survivors: A Network Meta-Analysis.Integrative cancer therapiesPooled it
- Yoga intervention on the fatigue-pain-sleep disturbance symptom cluster for breast cancer patients receiving adjuvant chemotherapy: a pilot randomized controlled trial.BMC complementary medicine and therapies · 2026Trial
- Article
- Prevalence of preoperative multidimensional frailty and associated factors in middle-aged and older patients with newly diagnosed breast cancer: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Predicting sleep disorder trajectories in older patients with chronic pain: an explainable machine learning approach.BMC psychiatry · 2026Article
- The impact of social determinants of health on mental and behavioral health trajectories of breast cancer survivors: A longitudinal cohort study.European journal of oncology nursing : the official journal of European Oncology Nursing Society · 2026Article
- Impact of low anterior resection syndrome after rectal surgery on sleep quality.Surgery today · 2025Article
- Quality of life, insomnia, attitudes and beliefs in women undergoing chemotherapy for breast cancer: a cross-sectional study in Amol city Northern Iran.BMC women's health · 2025Article
- Exploring the influence and identifying key predictors of sleep difficulties on health status in long-term breast cancer survivors: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Comparing the experiences of cancer survivors living with sleep disturbances between differing levels of psychological distress: a qualitative study.BMC psychiatry · 2024Article
- Current evidence supporting associations of DNA methylation measurements with survivorship burdens in cancer survivors: A scoping review.Cancer medicine · 2024Article
- A qualitative study of sleep in young breast cancer survivors: "No longer able to sleep through the night".Journal of cancer survivorship : research and practice · 2024Article
- Does use of health behaviours to cope with stress predict sleep impairment in trauma-exposed community adults?Stress and health : journal of the International Society for the Investigation of Stress · 2024Article
- Early change in fatigue, insomnia, and cognitive impairment and symptom severity 3 years post-treatment in breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundBreast cancer survivors (BCS) often report poor sleep quality and wakefulness throughout the night as the greatest challenges experienced during and posttreatment.
objectivesThis study aimed to elucidate characteristics of sleep disturbances and determine potential predictors that affect sleep disturbances in BCS for 2 years postchemotherapy.
methodsThis is a secondary analysis of data from the EPIGEN study, which longitudinally examined sociodemographic and cancer-related factors, lifestyle, symptom characteristics, and epigenetic factors at baseline prior to chemotherapy (T1), the midpoint (T2), 6-month (T3), 1-year (T4), and 2-year (T5) time points postchemotherapy. Temporal lifestyle changes, symptom characteristics, and epigenetic factors were explored using linear mixed-effects models with a random intercept. A linear regression model was fitted to identify significant predictors of sleep disturbances at each time point.
resultsIn 74 BCS with an average age of 51 years and 70% non-Hispanic White, BCS experienced severe sleep disturbances at T2, which gradually improved over time. Significant temporal changes in midsleep awakenings, early awakenings, and fatigue at work were observed, with disturbances being elevated at T2. Anxiety (T1, T2, and T4), fatigue (T3 and T4), and perceived stress (T3) were significant predictors after adjusting for radiation therapy, surgery, and adjuvant endocrine therapy. DISCUSSION: This study highlights that predictors of sleep disturbances change over time, with anxiety being a factor earlier in the treatment trajectory (prechemotherapy) and continuing over time with fatigue and perceived stress being involved later in the treatment trajectory. Our results indicate that symptom management strategies to address sleep disturbances should be tailored to the temporal factors that may change in severity during active treatment and early survivorship period. Findings gained from this study on sleep disturbance patterns and the potential risk factors can be incorporated into clinical practice in planning education and developing interventions.
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