Evidence map›Paper›PMID 35026603›Full record

ArticleBiochemical and biophysical research communications2022

Multi-component redox system for selective and potent antineoplastic activity towards ovarian cancer cells.

Debarshi Roy, Brenita Jenkins, Aqeeb Ali, Jacob R Herschmann, Michele Harris, Matibur Zamadar, Laken Simington, Odutayo Odunuga, Prakash Adhikari, Prabhakar Pradhan and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. A Redox-active Mn Porphyrin, MnTnBuOE-2-PyPOxidative medicine and cellular longevity · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Debarshi RoyDepartment of Biological Sciences, Alcorn State University, Lorman, MS, USA. Electronic address: droy@alcorn.edu.
Brenita JenkinsDepartment of Biological Sciences, Alcorn State University, Lorman, MS, USA.
Aqeeb AliDepartment of Chemistry and Biochemistry, Stephen F. Austin State University, Nacogdoches, TX, USA.
Jacob R HerschmannDepartment of Chemistry and Biochemistry, Stephen F. Austin State University, Nacogdoches, TX, USA.
Michele HarrisDepartment of Chemistry and Biochemistry, Stephen F. Austin State University, Nacogdoches, TX, USA.
Matibur ZamadarDepartment of Chemistry and Biochemistry, Stephen F. Austin State University, Nacogdoches, TX, USA. Electronic address: zamadarmr@sfasu.edu.
Laken SimingtonDepartment of Chemistry and Biochemistry, Stephen F. Austin State University, Nacogdoches, TX, USA.
Odutayo OdunugaDepartment of Chemistry and Biochemistry, Stephen F. Austin State University, Nacogdoches, TX, USA.
Prakash AdhikariDepartment of Physics and Astronomy, Mississippi State University, Mississippi State, MS, USA.
Prabhakar PradhanDepartment of Physics and Astronomy, Mississippi State University, Mississippi State, MS, USA.
Sanjay SarkarDepartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Mahesh PattabiramDepartment of Chemistry, University of Nebraska Kearney, Kearney, NE, USA.
Bidisha SenguptaDepartment of Chemistry and Biochemistry, Stephen F. Austin State University, Nacogdoches, TX, USA. Electronic address: bidisha.sengupta@sfasu.edu.
Stephen F. Austin State University · USAlcorn State University · USMississippi State University · USUniversity of Nebraska at Kearney · USUniversity of North Carolina at Chapel Hill · US

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PAUL L SORGEN · 2012 to 2026
$59.2M
Photonics probing of DNA mass density spatial structure for cancer diagnosticsR21CA260147 · NCI · MISSISSIPPI STATE UNIVERSITY · PI PRADHAN, PRABHAKAR · 2021 to 2021
$397k
NCI NIH HHS R21 CA260147NIGMS NIH HHS P20 GM103427NIGMS NIH HHS P20 GM103476
6 · The paper itself

Abstract

Ovarian cancer is the deadliest gynecological cancer which rarely causes symptoms, and goes undetected until reaching the advanced stage of drug-resistant metastases. The cationic porphyrin meso-tetra(4-N-methylpyridyl)porphine (TMPyP) is a well-known photosensitizer (PS) used in photodyamic therapy (PDT) for curing cancer due to its strong affinity for DNA and high yield of reactive oxygen species (ROS) upon light activation. The practicality to irradiate tumor cells alone in the physiological system being slim (due to the close proximity of healthy cells and tumors), we looked for a variation in the PDT using a mixture of TMPyP with 1,5-dihydroxynapthalene (DHN) and Fe(III) ions at a mole ratio of 1:20:17 (drug combo) respectively in aqueous solution. The drug combo needs no photoactivation in H

Indexed as

AcidsAnimalsAntineoplastic AgentsCell Line, TumorCell ProliferationCell SurvivalFemaleFibroblastsHumansHydrogen PeroxideMiceNaphtholsNaphthoquinonesOvarian NeoplasmsOxidation-ReductionPorphyrins1,5-dihydroxynaphthaleneAcidsAntineoplastic AgentsHydrogen PeroxidejugloneNaphtholsNaphthoquinonesPorphyrinstetra(4-N-methylpyridyl)porphineJugloneOxidative stressReactive oxygen speciesSinglet oxygen

Identifiers

PMID35026603
PMCPMC8959003
OpenAlexW4206128375

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.