Evidence map›Paper›PMID 35026559›Full record

ReviewCarbohydrate research2022

Synthesis of self-assembled hyaluronan based nanoparticles and their applications in targeted imaging and therapy.

Kunli Liu, Xuefei Huang

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Carbohydrate research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kunli LiuDepartment of Chemistry, Michigan State University, East Lansing, MI, 48824, USA; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Xuefei HuangDepartment of Chemistry, Michigan State University, East Lansing, MI, 48824, USA; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, 48824, USA; Department of Biomedical Engineering, Michigan State University, East Lansing, MI, 48824, USA. Electronic address: huangxu2@msu.edu.
Michigan State University · US

Funding

Homogeneous Heparan Sulfate Glycopeptides: Synthetic and Functional StudiesR01GM072667 · NIGMS · UNIVERSITY OF TOLEDO · PI HUANG, XUEFEI · 2005 to 2024
$5.1M
NIGMS NIH HHS R01 GM072667
6 · The paper itself

Abstract

Hyaluronan (HA) is a polysaccharide consisting of repeating disaccharides of N-acetyl-d-glucosamine and d-glucuronic acid. There are increasing interests in utilizing self-assembled HA nanoparticles (HA-NPs) for targeted imaging and therapy. The principal endogenous receptor of HA, cluster of differentiation 44 (CD44), is overexpressed on many types of tumor cells as well as inflammatory cells in human bodies. Active targeting from HA-CD44 mediated interaction and passive targeting due to the enhanced permeability retention (EPR) effect could lead to selective accumulation of HA-NPs at targeted disease sites. This review focuses on the synthesis strategies of self-assembled HA-NPs, as well as their applications in therapy and biomedical imaging.

Indexed as

Hyaluronic AcidNanoparticlesCell Line, TumorHumansHyaluronan ReceptorsHyaluronan ReceptorsHyaluronic AcidCD44Drug deliveryHyaluronanMolecular imagingNanotechnologySelf assembly

Identifiers

PMID35026559
PMCPMC8792315
OpenAlexW4206029259

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.