Evidence map›Paper›PMID 35026299›Full record

ArticleChest2022

Trends in Geriatric Conditions Among Older Adults Admitted to US ICUs Between 1998 and 2015.

Julien Cobert, Sun Young Jeon, John Boscardin, Allyson C Chapman, Lauren E Ferrante, Sei Lee, Alexander K Smith

Open access · greenAbstract read
In one paragraph

Article in Chest, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Acute Respiratory Distress Syndrome: No Disease for Old Men.American journal of respiratory and critical care medicine · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Long-term recovery after critical illness in older adults.Current opinion in critical care · 2022
    Review
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Julien CobertAnesthesia Service, San Francisco VA Health Care System, San Francisco, CA; Department of Anesthesiology, University of California, San Francisco, CA. Electronic address: julien.cobert@ucsf.edu.
Sun Young JeonDivision of Geriatrics, Department of Medicine, University of California, San Francisco, CA; Department of Geriatrics, Palliative, and Extended Care, Veterans Affairs Medical Center, San Francisco, CA.
John BoscardinDivision of Geriatrics, Department of Medicine, University of California, San Francisco, CA; Department of Geriatrics, Palliative, and Extended Care, Veterans Affairs Medical Center, San Francisco, CA; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA.
Allyson C ChapmanDivision of Critical Care and Palliative Medicine, Department of Internal Medicine, University of California, San Francisco, CA; Department of Surgery, University of California, San Francisco, CA.
Lauren E FerranteSection of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT.
Sei LeeDivision of Geriatrics, Department of Medicine, University of California, San Francisco, CA; Department of Geriatrics, Palliative, and Extended Care, Veterans Affairs Medical Center, San Francisco, CA.
Alexander K SmithDivision of Geriatrics, Department of Medicine, University of California, San Francisco, CA; Department of Geriatrics, Palliative, and Extended Care, Veterans Affairs Medical Center, San Francisco, CA.
University of California, San Francisco · USSan Francisco VA Medical Center · USSan Francisco VA Health Care System · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Denise Esserman · 2002 to 2026
$37.9M
Residing in the Community with Dementia at the End of Life: Understanding Hospice Use and Residential SettingP30AG028741 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ORNA INTRATOR · 2010 to 2026
$21.9M
VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Louise C. Walter · 2013 to 2026
$19.9M
Unnecessary and Harmful Medication Use in Older Adults with DementiaP01AG066605 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KENNETH E. COVINSKY · 2020 to 2026
$17.7M
The PREDICT Study (PRE-ICU Determinants of Post-ICU FunCTional Outcomes among Older Adults)K76AG057023 · NIA · YALE UNIVERSITY · PI FERRANTE, LAUREN · 2017 to 2022
$1.3M
Mentoring Researchers in Prognosis Research in Alzheimer’s Disease and Related DementiasK24AG068312 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alexander Keliimoeanu Smith · 2020 to 2026
$1.2M
Mentoring Patient-Oriented Research to Individualize Care for Hospitalized Older Adults with and without Alzheimer's Disease and Related DementiasK24AG066998 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Sei Lee · 2021 to 2026
$1.1M
NCATS NIH HHS UL1 TR001863NIA NIH HHS K24 AG066998NIA NIH HHS K24 AG068312NIA NIH HHS K76 AG057023NIA NIH HHS P01 AG066605NIA NIH HHS P30 AG021342NIA NIH HHS P30 AG028741NIA NIH HHS P30 AG044281
6 · The paper itself

Abstract

backgroundOlder adults are increasingly admitted to the ICU, and those with disabilities, dementia, frailty, and multimorbidity are vulnerable to adverse outcomes. Little is known about how pre-existing geriatric conditions have changed over time. RESEARCH QUESTION: How have changes in disability, dementia, frailty, and multimorbidity in older adults admitted to the ICU changed from 1998 through 2015? STUDY DESIGN AND

methodsMedicare-linked Health and Retirement Survey (HRS) data identifying patients 65 years of age and older admitted to an ICU between 1998 and 2015. ICU admission was the unit of analysis. Year of ICU admission was the exposure. Disability, dementia, frailty, and multimorbidity were identified based on responses to HRS surveys before ICU admission. Disability represented the need for assistance with ≥ 1 activity of daily living. Dementia used cognitive and functional measures. Frailty included deficits in ≥ 2 domains (physical, nutritive, cognitive, or sensory function). Multimorbidity represented ≥ 3 self-reported chronic diseases. Time trends in geriatric conditions were modeled as a function of year of ICU admission and were adjusted for age, sex, race or ethnicity, and proxy interview status.

resultsAcross 6,084 ICU patients, age at admission increased from 77.6 years (95% CI, 76.7-78.4 years) in 1998 to 78.7 years (95% CI, 77.5-79.8 years) in 2015 (P < .001 for trend). The adjusted proportion of ICU admissions with pre-existing disability rose from 15.5% (95% CI, 12.1%-18.8%) in 1998 to 24.0% (95% CI, 18.5%-29.6%) in 2015 (P = .001). Rates of dementia did not change significantly (P = .21). Frailty increased from 36.6% (95% CI, 30.9%-42.3%) in 1998 to 45.0% (95% CI, 39.7%-50.2%) in 2015 (P = .04); multimorbidity rose from 54.4% (95% CI, 49.2%-59.7%) in 1998 to 71.8% (95% CI, 66.3%-77.2%) in 2015 (P < .001).

interpretationRates of pre-existing disability, frailty, and multimorbidity in older adults admitted to ICUs increased over time. Geriatric principles need to be deeply integrated into the ICU setting.

Indexed as

DementiaFrailtyAgedGeriatric AssessmentHumansIntensive Care UnitsMedicareUnited Statesdementiadisabilityepidemiologyfrailtygeriatrics

Identifiers

PMID35026299
PMCPMC9248079
OpenAlexW4206425842

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.