Evidence map›Paper›PMID 35025698›Full record

ArticleAutophagy2022

Autophagy regulates differentiation of ovarian granulosa cells through degradation of WT1.

Tong Shao, Hanni Ke, Ran Liu, Lan Xu, Shuang Han, Xiruo Zhang, Yujie Dang, Xue Jiao, Wei Li, Zi-Jiang Chen and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Autophagy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
19.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 125 citations in OpenAlex.

  1. Article
  2. A Novel Role of DELTEX2 in Maintaining Genomic Stability of Granulosa Cells During Ovarian Aging.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Article
  4. Article
  5. Ovarian toxic effects of micro- and nanoplastics (Review).Experimental and therapeutic medicine · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Mechanistic study on the role of multi-pathway autophagy in ovarian aging: literature review.Apoptosis : an international journal on programmed cell death · 2025
    Review
  16. Article
  17. Cells · 2025
    Article
  18. Article
  19. Review
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Tong ShaoCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Hanni KeCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Ran LiuCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Lan XuCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Shuang HanCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Xiruo ZhangCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Yujie DangCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Xue JiaoCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Wei LiState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0002-6235-0749
Zi-Jiang ChenCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Yingying QinCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.ORCID 0000-0002-0319-7799
Shidou ZhaoCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.ORCID 0000-0003-4722-1575
Shandong University · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian granulosa cells (GCs) proliferate and differentiate along with follicular growth, and this is indispensable for oocyte development and female fertility. Although the role of macroautophagy/autophagy in ovarian function has been reported, its contribution to the regulation of GC characteristics remains elusive. The siRNA-mediated knockdown of two key autophagy-related genes

Indexed as

AutophagyGranulosa CellsAnimalsChloroquineEstradiolFemaleRNA, Small InterferingTranscription FactorsChloroquineEstradiolRNA, Small InterferingTranscription FactorsAutophagydifferentiationgranulosa cellspremature ovarian insufficiencyWT1

Identifiers

PMID35025698
PMCPMC9450966
OpenAlexW4206380528

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.