Evidence map›Paper›PMID 35025689›Full record

ArticleJCO global oncology2022

HIV and Hodgkin Lymphoma Survival: A Prospective Study in Botswana.

Kaelo Moahi, Tlotlo Ralefala, Isaac Nkele, Scott Triedman, Aliyah Sohani, Zola Musimar, Jason Efstathiou, Philipe Armand, Shahin Lockman, Scott Dryden-Peterson

Open access · goldAbstract read
In one paragraph

Article in JCO global oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
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  4. Quality of life among non-metastatic breast cancer survivors in Botswana.Journal of cancer survivorship : research and practice · 2025
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  14. CD4Open life sciences · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 2 countries.

Kaelo MoahiDepartment of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-3704-4854
Tlotlo RalefalaPrincess Marina Hospital, Ministry of Health and Wellness, Gaborone, Botswana.ORCID 0000-0003-1150-3722
Isaac NkeleBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Scott TriedmanDepartment of Radiation Oncology, Warren Alpert Medical School, Providence, RI.ORCID 0000-0002-0894-2196
Aliyah SohaniDepartment of Pathology, Massachusetts General Hospital, Boston, MA.ORCID 0000-0002-6307-4854
Zola MusimarPrincess Marina Hospital, Ministry of Health and Wellness, Gaborone, Botswana.ORCID 0000-0001-6698-0759
Jason EfstathiouDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, MA.ORCID 0000-0003-0996-0350
Philipe ArmandDepartment of Medical Oncology/Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA.ORCID 0000-0001-6098-1603
Shahin LockmanBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.ORCID 0000-0002-5384-9716
Scott Dryden-PetersonBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.ORCID 0000-0002-8487-9731
Brigham and Women's Hospital · USMinistry of Health · BWBotswana Harvard AIDS Institute Partnership · BWChildren's Hospital of Philadelphia · USDana-Farber Cancer Institute · USHarvard University · USMassachusetts General Hospital · USProvidence College · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DAVID S METZGER · 1999 to 2026
$78.6M
Covid-19-related cervical cancer treatment interruption and role of neoadjuvant chemotherapyR01CA236546 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI DRYDEN-PETERSON, SCOTT · 2019 to 2023
$2.5M
Mentoring in Patient-Oriented HIV Research in the Era of Universal ARTK24AI131928 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAHIN LOCKMAN · 2017 to 2026
$1.9M
Risk factors for early morbidity and mortality of HIV-exposed uninfected infantsK23AI091434 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI DRYDEN-PETERSON, SCOTT · 2012 to 2016
$659k
Planning for NCDs Research Center of Excellence in Southern AfricaP20CA210283 · NCI · BOTSWANA-HARVARD AIDS INSTITUTE · PI CHABNER, BRUCE ALLAN, LOCKMAN, SHAHIN · 2016 to 2017
$476k
PROTON THERAPY RESEARCH AND TREATMENT CENTERC06CA059267 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI GOITEIN, MICHAEL · 1992 to 1995
–
NCI NIH HHS C06 CA059267NCI NIH HHS P20 CA210283NCI NIH HHS R01 CA236546NIAID NIH HHS K23 AI091434NIAID NIH HHS K24 AI131928NIAID NIH HHS P30 AI045008NIAID NIH HHS P30 AI060354
6 · The paper itself

Abstract

purposePeople living with HIV (PLWH) experience increased risk of Hodgkin lymphoma (HL) despite effective initiation of antiretroviral therapy (ART). In high-income countries, outcomes following HIV HL have been reported to be non-differential, or inferior for PLWH. We sought to assess the effect of HIV on HL survival in Botswana, an African country with a generalized HIV epidemic and high ART coverage, to describe a context more reflective of global HIV populations. PATIENTS AND

methodsIn the Thabatse Cancer Cohort, consenting participants initiating treatment for HL at one of four cancer centers in Botswana were enrolled from 2010 to 2020. Patients were followed quarterly for up to 5 years. The impact of HIV on survival following treatment initiation was assessed using an inverse probability-weighted Cox marginal structural model adjusted for age, performance status, and disease stage.

resultsSeventy-eight new HL cases were enrolled, 47 (60%) were PLWH and 31 (40%) were HIV-uninfected. Baseline characteristics were similar between groups. The majority (61%) of patients presented with regional disease (stage I or II) with no statistically significant difference by HIV status (

conclusionIn this cohort of patients treated for HL in Botswana, survival in PLWH (87% on long-standing ART) was at least as good as in individuals without HIV.

Indexed as

HIV InfectionsHodgkin DiseaseBotswanaCD4 Lymphocyte CountHumansProspective Studies

Identifiers

PMID35025689
PMCPMC8769145
OpenAlexW4205188260

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.