ArticleScience (New York, N.Y.)2022
Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production.
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Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers, 1 of them a synthesis that pooled it.
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136citing papers in PubMed, 1 pooled it
26.3field-weighted citation impact, top 1% of its field
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Who cites it
136 citing papers in PubMed, 1 synthesis or guideline pooled it, 216 citations in OpenAlex.
- Systematic Review of Interleukin-35 in Endothelial Dysfunction: A New Target for Therapeutic Intervention.Mediators of inflammation · 2025Pooled it
- MNS induces antiviral protection and suppresses inflammation.Annals of medicine · 2026Article
- Cooperation between Adh and OR5M11 contributes to the lung pathogenicity of Actinobacillus pleuropneumoniae by facilitating the NLRP3-mediated inflammatory response.Veterinary research · 2026Article
- PPE57 Cooperates with MmpL3 to Mediate Bacterial Lipid Transport and Promote Persistent Infection ofMicroorganisms · 2026Article
- Inflammation in atherosclerosis: Drivers, mechanisms and therapies.Acta pharmaceutica Sinica. B · 2026Review
- RELM-β Augmented Hypoxia-Induced Pulmonary Hypertension Through Interacting with GIPC1, OR1N1 and CLIC4.Cardiovascular drugs and therapy · 2026Article
- Deciphering the interplay between SGLT2 inhibition, CCL4, and angina pectoris: A Mendelian randomization study.Medicine · 2026Article
- Article
- Ectopic Olfactory Receptors in Oral Health and Disease: Molecular Links Between Chemosensing, Tissue Repair, Inflammation, and Cancer.International journal of molecular sciences · 2026Review
- Metabolic Reprogramming-Driven Cardiovascular Immune Damage: From Glyco-Lipotoxicity and Epigenetic Memory to Multidimensional Cross-Organ Communication Networks.International journal of molecular sciences · 2026Review
- Encapsulation of Exosomal Volatile Organic Compounds for Modulating the NF-κB Pathway in Monocytes.ACS bio & med chem Au · 2026Article
- Whole-transcriptome analysis of Aortic Stenosis reveals dysregulated RNA networks, immune cell infiltration, and NADK2 as a candidate regulator.Hereditas · 2026Article
- The Emerging Role of Olfactory Receptors: From Genomics to Precision Medicine.Molecular diagnosis & therapy · 2026Review
- Inflammation-modulating agents in chronic limb-threatening ischemia: a narrative review of therapeutic potential and future directions.Annals of medicine and surgery (2012) · 2026Article
- The sphingolipid metabolite sphingosine protects against hypertension by targeting metabolic-inflammatory crosstalk via the NLRP3 inflammasome.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Vertebrate-wide transcriptomic screening identifies immune cell-specific expression of the conserved OR-κ gene.Zoological letters · 2026Article
- Nanomaterials and exercise interventions: A synergistic approach for atherosclerosis therapy (Review).International journal of molecular medicine · 2026Review
- Circulating cfdna: A novel biomarker for preventing early recurrence in ischemic stroke.Journal of thrombosis and thrombolysis · 2026Review
- When Smell Drives Swell: Olfr2 Fuels Inflammation in AAA.Circulation research · 2026Article
- Mitochondria-Associated Endoplasmic Reticulum Membrane Biomarkers in Coronary Heart Disease and Atherosclerosis: A Transcriptomic and Mendelian Randomization Study.Current issues in molecular biology · 2026Article
76 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
29 authors at 7 institutions in 3 countries.
Marco OrecchioniLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-3602-8510
Kouji KobiyamaLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Holger WinkelsLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0003-1333-2031
Yanal GhoshehLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-3733-2098
Sara McArdleHistology and Microscopy Core Facility, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0003-3795-3772
Zbigniew MikulskiHistology and Microscopy Core Facility, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-1918-9216
William B KiossesHistology and Microscopy Core Facility, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0003-1832-9050
Zhichao FanLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0001-5385-9626
Lai WenLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0001-9760-3403
Yunmin JungLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-4734-5837
Payel RoyLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0003-2511-068X
Amal J AliLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-7418-4186
Yukiko MiyamotoDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-5650-699X
Matthew ManganInstitute of Innate Immunity, University Hospital Bonn, 53127 Bonn, Germany.
Jeffrey MakingsLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Zhihao WangLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-2597-4464
Angela DennHistology and Microscopy Core Facility, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-1844-4668
Jenifer VallejoLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-4836-8854
Michaela OwensLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Christopher P DurantLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0003-1374-8141
Simon BraumannDepartment of Internal Medicine III, Division of Cardiology, Heart Center, University Hospital of Cologne, 50937 Cologne, Germany.
Navid MaderDepartment of Cardiothoracic Surgery, Heart Center, University Hospital of Cologne, 50937 Cologne, Germany.ORCID 0000-0001-6980-5761
Lin LiLerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0003-1578-9182
Hiroaki MatsunamiMolecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27708, USA.ORCID 0000-0002-8850-2608
Lars EckmannDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-7987-8742
Eicke LatzInstitute of Innate Immunity, University Hospital Bonn, 53127 Bonn, Germany.
Zeneng WangLerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0002-6455-8228
Stanley L HazenLerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0001-7124-6639
Klaus LeyLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0001-9339-3672
La Jolla Institute for Immunology · USUniversity Hospital Bonn · DEUniversity Hospital Cologne · DEUniversity of California San Diego · USCleveland Clinic · USCleveland Clinic Lerner College of Medicine · USDuke University · US
Funding
Transcriptional GenomicsP01HL088093 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WITZTUM, JOSEPH L. · 2008 to 2018
$26.4MProject 4: APOB-specific CD4 and CD8 T cells exacerbate atherosclerosisP01HL136275 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Catherine C Hedrick · 2017 to 2026
$25.5MGut Flora Metabolism of Dietary Phosphatidylcholine and CVDR01HL103866 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L · 2010 to 2023
$10.8MSan Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8MVascular macrophages and T cells in atherosclerosisR35HL145241 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2019 to 2025
$5.9MMyeloid cell interactions with T cells in atherosclerosisR01HL115232 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2012 to 2018
$3.2MDiet, Gut Microbiota, and Heart FailureR01HL126827 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L, TANG, WAI HONG WILSON · 2016 to 2019
$3.1MDietary Choline, Gut Microbiota, and Susceptibility for Chronic Kidney DiseaseR01DK106000 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L, TANG, WAI HONG WILSON · 2015 to 2018
$2.8MMolecular mechanism and preclinical translation of beta2 integrin auto-inhibition on neutrophil arrest and inflammationR01HL145454 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI FAN, ZHICHAO · 2019 to 2023
$2.1MMicrobial Trimethylamine Lyases and AtherosclerosisR01HL130819 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI WANG, ZENENG · 2016 to 2019
$1.7MSuper-resolution confocal microscopeS10OD021831 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2017 to 2017
$566kFACSAria II Cell SorterS10RR027366 · NCRR · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROFT, MICHAEL · 2011 to 2011
$514kAmerican Heart Association-American Stroke Association 18CDA34110426American Heart Association-American Stroke Association 18POST34060251NCRR NIH HHS S10 RR027366NHLBI NIH HHS P01 HL088093NHLBI NIH HHS P01 HL136275NHLBI NIH HHS R01 HL103866NHLBI NIH HHS R01 HL115232NHLBI NIH HHS R01 HL126827NHLBI NIH HHS R01 HL130819NHLBI NIH HHS R01 HL145454NHLBI NIH HHS R35 HL145241NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK106000NIH HHS S10 OD021831
Abstract
Atherosclerosis is an inflammatory disease of the artery walls and involves immune cells such as macrophages. Olfactory receptors (OLFRs) are G protein–coupled chemoreceptors that have a central role in detecting odorants and the sense of smell. We found that mouse vascular macrophages express the olfactory receptor
Indexed as
AdultAldehydesAnimalsAortaAtherosclerosisHumansInflammasomesInterleukin-1Interleukin-1alphaInterleukin-1betaLipid PeroxidationMacrophagesMiceMice, Inbred C57BLMiddle AgedNLR Family, Pyrin Domain-Containing 3 ProteinAldehydescaprylic aldehydeIL1B protein, humanIL1B protein, mouseInflammasomesInterleukin-1Interleukin-1alphaInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanNlrp3 protein, mouseOlfr2 protein, mouseReceptors, Odorant
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