Evidence map›Paper›PMID 35025117›Full record

ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2022

Investigating the effects of compound paralogous EPHB receptor mutations on mouse facial development.

Sarah T Mincer, Terren K Niethamer, Teng Teng, Jeffrey O Bush, Christopher J Percival

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sarah T MincerInterdepartmental Doctoral Program in Anthropological Sciences, Stony Brook University, Stony Brook, New York, USA.ORCID 0000-0003-2275-7971
Terren K NiethamerProgram in Craniofacial Biology, University of California San Francisco, San Francisco, California, USA.
Teng TengProgram in Craniofacial Biology, University of California San Francisco, San Francisco, California, USA.
Jeffrey O BushProgram in Craniofacial Biology, University of California San Francisco, San Francisco, California, USA.
Christopher J PercivalDepartment of Anthropology, Stony Brook University, Stony Brook, New York, USA.
University of California, San Francisco · USStony Brook University · US

Funding

Mechanisms of Eph/Ephrin signaling in craniofacial morphogenesis and craniofrontonasal syndromeR01DE023337 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BUSH, JEFFREY OHMANN · 2013 to 2021
$4.3M
NIDCR NIH HHS R01 DE023337
6 · The paper itself

Abstract

backgroundVariation in facial shape may arise from the combinatorial or overlapping actions of paralogous genes. Given its many members, and overlapping expression and functions, the EPH receptor family is a compelling candidate source of craniofacial morphological variation. We performed a detailed morphometric analysis of an allelic series of E14.5 Ephb1-3 receptor mutants to determine the effect of each paralogous receptor gene on craniofacial morphology.

resultsWe found that Ephb1, Ephb2, and Ephb3 genotypes significantly influenced facial shape, but Ephb1 effects were weaker than Ephb2 and Ephb3 effects. Ephb2

conclusionsThis study provides a detailed assessment of the effects of Ephb receptor gene paralogs on E14.5 mouse facial morphology and demonstrates how the loss of specific receptors contributes to facial dysmorphology.

Indexed as

Ephrin-B1Maxillofacial DevelopmentReceptor, EphB1Receptor, EphB3Receptors, Eph FamilyAnimalsFaceMiceMutationReceptor, EphB2Ephb2 protein, mouseEphrin-B1Receptor, EphB1Receptor, EphB2Receptor, EphB3Receptors, Eph Familyadditive genetic effectsallometrycraniofacialEfnb1EPHRIN-B1morphological variation

Identifiers

PMID35025117
PMCPMC9924224
OpenAlexW4205518997

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.