ArticleBiomechanics and modeling in mechanobiology2022
Fluid-structure interaction simulation of tissue degradation and its effects on intra-aneurysm hemodynamics.
Article in Biomechanics and modeling in mechanobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 33 citations in OpenAlex.
- A multi-fractal vascular tree model for characterizing blood flow in cardiovascular system.Scientific reports · 2026Article
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- Computational fluid dynamics analysis of hemodynamics in bicuspid aortic valve with giant aneurysm.Journal of cardiothoracic surgery · 2026Article
- An open-source computational framework for immersed fluid-structure interaction modeling using FEBio and MFEM.Engineering with computers · 2026Article
- Hemodynamic response to stent-induced aneurysm deformation in patient-specific internal carotid artery cases: A computational study.Scientific reports · 2025Article
- Ruptured vertebrobasilar junction aneurysm coexisting with isolated interrupted aortic arch and basilar artery hypoplasia in an adult female: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Impact of anatomical variations of the circle of Willis on the blood flow within unruptured intracranial aneurysm.Quantitative imaging in medicine and surgery · 2025Article
- Computational assessment of blood lipid influence on hemodynamics in human retinal vessels.Scientific reports · 2025Article
- Anatomical location-related hemodynamic variations are associated with atherosclerosis in the middle cerebral artery: a preliminary cross-sectional 4D flow and 3D vessel wall MRI study.Quantitative imaging in medicine and surgery · 2025Article
- Characteristics of transition to turbulence in a healthy thoracic aorta using large eddy simulation.Scientific reports · 2025Article
- Study of blood flow patterns in a stenosed artery through the combined effect of body acceleration and generalized womersley solution.Scientific reports · 2025Article
- Plasma exosomes from patients with coronary artery disease promote atherosclerosis via impairing vascular endothelial junctions.Scientific reports · 2024Article
- On flow fluctuations in ruptured and unruptured intracranial aneurysms: resolved numerical study.Scientific reports · 2024Article
- Hemodynamic effects of entry and exit tear size in aortic dissection evaluated with in vitro magnetic resonance imaging and fluid-structure interaction simulation.Scientific reports · 2023Article
- Haemodynamic Effects on the Development and Stability of Atherosclerotic Plaques in Arterial Blood Vessel.Interdisciplinary sciences, computational life sciences · 2023Article
- Fluid dynamics in intracranial aneurysms treated with flow-diverting stents: effect of multiple geometrical parameters.Journal of fluid mechanics · 2023Article
- Modeling Dynamics of the Cardiovascular System Using Fluid-Structure Interaction Methods.Biology · 2023Review
- Fluid-structure interaction (FSI) simulation for studying the impact of atherosclerosis on hemodynamics, arterial tissue remodeling, and initiation risk of intracranial aneurysms.Biomechanics and modeling in mechanobiology · 2022Article
- On the Potential Self-Amplification of Aneurysms Due to Tissue Degradation and Blood Flow Revealed From FSI Simulations.Frontiers in physiology · 2021Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Tissue degradation plays a crucial role in vascular diseases such as atherosclerosis and aneurysms. Computational modeling of vascular hemodynamics incorporating both arterial wall mechanics and tissue degradation has been a challenging task. In this study, we propose a novel finite element method-based approach to model the microscopic degradation of arterial walls and its interaction with blood flow. The model is applied to study the combined effects of pulsatile flow and tissue degradation on the deformation and intra-aneurysm hemodynamics. Our computational analysis reveals that tissue degradation leads to a weakening of the aneurysmal wall, which manifests itself in a larger deformation and a smaller von Mises stress. Moreover, simulation results for different heart rates, blood pressures and aneurysm geometries indicate consistently that, upon tissue degradation, wall shear stress increases near the flow-impingement region and decreases away from it. These findings are discussed in the context of recent reports regarding the role of both high and low wall shear stress for the progression and rupture of aneurysms.
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