Evidence map›Paper›PMID 35024926›Full record

SynthesisSurgical endoscopy2022

Impact of change in the surgical plan based on indocyanine green fluorescence angiography on the rates of colorectal anastomotic leak: a systematic review and meta-analysis.

Sameh Hany Emile, Sualeh Muslim Khan, Steven D Wexner

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Surgical endoscopy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06871787 (Evaluation of Bowel Anastomoses During Gynecologic Oncology Surgery Using Near-Infrared Fluorescence Imaging With Indocyanine Green), which is not on this map. Cited by 49 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 10 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06871787 phase4not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Evaluation of Bowel Anastomoses During Gynecologic Oncology Surgery Using Near-Infrared Fluorescence Imaging With Indocyanine Green

TypeinterventionalSponsorIstanbul UniversityRan2025 to 2027Enrolled50ConditionsGynecologic Cancers, Ovarian Cancer, Endometrial Cancers, Cervical CancersArmsIndocyanine Green, Near-Infrared Fluorescence Imaging System
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 10 syntheses or guidelines pooled it, 74 citations in OpenAlex.

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  18. Use of Human Amnion/Chorion Membrane as a Protective Barrier in Complicated Diverticulitis Patients Undergoing Colorectal Resections.European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes · 2026
    Article
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  20. AUGUR-AIM: Clinical validation of an artificial intelligence indocyanine green fluorescence angiography expert representer.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Sameh Hany EmileGeneral Surgery Department, Mansoura University Hospitals, Mansoura University, Mansoura, 35516, Egypt. sameh200@hotmail.com.ORCID 0000-0001-7854-5244
Sualeh Muslim KhanDow Medical College, Dow University of Health Sciences, Karachi, Pakistan.
Steven D WexnerDepartment of Colorectal Surgery, Cleveland Clinic Florida, Weston, FL, USA.
Cleveland Clinic Florida · USDow University of Health Sciences · PKMansoura University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the present study, patients with colorectal anastomoses that were assessed with indocyanine green (ICG) fluorescence angiography (FA) were compared to patients who had only white light visual inspection of their anastomosis. The impact of change in surgical plan guided by ICG-FA on anastomotic leak (AL) rates was assessed.

methodsPubMed, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials were queried for eligible studies. Studies included were comparative cohort studies and randomized trials that compared perfusion assessment of colorectal anastomosis with ICG-FA and inspection under white light. Main outcome measures were change in surgical plan guided by ICG-FA and rates of AL. Risk of bias was assessed using RoB-2 and ROBINS-1 tools. Differences between the two groups in categorical and continuous variables were expressed as odds ratio (OR) with 95% confidence interval (CI) and weighted mean difference.

resultsThis systematic review included 27 studies comprising 8786 patients (48.5% males). Using ICG-FA was associated with significantly lower odds of AL (OR 0.452; 95% CI 0.366-0.558) and complications (OR 0.747; 95% CI 0.592-0.943) than the control group. The weighted mean rate of change in surgical plan based on ICG-FA was 9.6% (95% CI 7.3-11.8) and varied from 0.64% to 28.75%. A change in surgical plan was associated with significantly higher odds of AL (OR 2.73; 95% CI 1.54-4.82). LIMITATIONS: Technical heterogeneity due to using different dosage of ICG and statistical heterogeneity in operative time and complication rates.

conclusionAssessment of colorectal anastomoses with ICG-FA is likely to be associated with lower odds of anastomotic leak than is traditional white light assessment. Change in plan based on ICG-FA may be associated with higher odds of AL. PROSPERO registration number: CRD42021235644.

Indexed as

Anastomotic LeakColorectal NeoplasmsAnastomosis, SurgicalFemaleFluorescein AngiographyHumansIndocyanine GreenMaleIndocyanine GreenChange in planColorectal anastomosisFluorescence angiographyIndocyanine greenLeakMeta-analysis

Identifiers

PMID35024926
OpenAlexW4206581477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.