Evidence map›Paper›PMID 35024853›Full record

ArticleThe Journal of infectious diseases2022

Intrauterine Fetal Demise in the Third Trimester of Pregnancy Associated With Mild Infection With the SARS-CoV-2 Delta Variant Without Protection From Vaccination.

Minhui Guan, Eric Johannesen, Cynthia Y Tang, Albert L Hsu, Courtney L Barnes, Megan Burnam, Jane A McElroy, Xiu-Feng Wan

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Observational
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Minhui GuanCenter for Influenza and Emerging Infectious Diseases, University of Missouri, Columbia, Missouri, USA.
Eric JohannesenSchool of Medicine, University of Missouri, Columbia, Missouri, USA.
Cynthia Y TangCenter for Influenza and Emerging Infectious Diseases, University of Missouri, Columbia, Missouri, USA.
Albert L HsuSchool of Medicine, University of Missouri, Columbia, Missouri, USA.
Courtney L BarnesSchool of Medicine, University of Missouri, Columbia, Missouri, USA.
Megan BurnamSchool of Medicine, University of Missouri, Columbia, Missouri, USA.
Jane A McElroySchool of Medicine, University of Missouri, Columbia, Missouri, USA.
Xiu-Feng WanCenter for Influenza and Emerging Infectious Diseases, University of Missouri, Columbia, Missouri, USA.
University of Missouri · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a higher infection rate in pregnant women than age-matched adults. With increased infectivity and transmissibility, the Delta variant is predominant worldwide.

methodsIn this study, we describe intrauterine fetal demise in unvaccinated women with mild symptoms of SARS-CoV-2 Delta variant infection.

resultsHistology and elevated proinflammatory responses of the placenta suggest that fetal demise was associated with placental malperfusion due to Delta variant infection.

conclusionsThis study suggests that the Delta variant can cause severe morbidity and mortality to fetuses. Vaccination should continue to be advocated and will likely continue to reduce SARS-CoV-2 infection risks for pregnant women and their fetuses.

Indexed as

Fetal DeathStillbirthAdultCOVID-19FemaleHumansInfectious Disease Transmission, VerticalPlacentaPregnancyPregnancy Complications, InfectiousPregnancy Trimester, ThirdSARS-CoV-2COVID-19Delta variantintrauterine fetal demisepregnancySARS-CoV-2

Identifiers

PMID35024853
PMCPMC8807234
OpenAlexW4205986499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.