Evidence map›Paper›PMID 35024686›Full record

ArticleJID innovations : skin science from molecules to population health2022

Loricrin and NRF2 Coordinate Cornification.

Yosuke Ishitsuka, Tatsuya Ogawa, Yoshiyuki Nakamura, Noriko Kubota, Yasuhiro Fujisawa, Rei Watanabe, Naoko Okiyama, Manabu Fujimoto, Dennis R Roop, Akemi Ishida-Yamamoto

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PubMed Full text at PMC Publisher
In one paragraph

Article in JID innovations : skin science from molecules to population health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. The Epidermis: Redox Governor of Health and Diseases.Antioxidants (Basel, Switzerland) · 2021
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Yosuke IshitsukaDepartment of Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan.
Tatsuya OgawaDepartment of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Yoshiyuki NakamuraDepartment of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Noriko KubotaDepartment of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Yasuhiro FujisawaDepartment of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Rei WatanabeDepartment of Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan.
Naoko OkiyamaDepartment of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Manabu FujimotoDepartment of Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan.
Dennis R RoopDepartment of Dermatology and Charles C. Gates Center for Regenerative Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Akemi Ishida-YamamotoDepartment of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
University of Tsukuba · JPThe University of Osaka · JPAsahikawa Medical University · JPUniversity of Colorado Anschutz Medical Campus · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cornification involves cytoskeletal cross-linkages in corneocytes (the brick) and the secretion of lipids/adhesion structures to the interstitial space (the mortar). Because the assembly of lipid envelopes precedes corneocyte maturation, loricrin is supposed to be dispensable for the protection against desiccation. Although the phenotypes of

Indexed as

CD, corneodesmosomeCDSN, corneodesmosinCE, cornified envelopeCEf, immature/fragile cornified envelopeDKO, Lor–Nrf2 double knockoutDMF, dimethyl fumarateKC, keratinocyteK, keratinLG, lamellar granuleLKO, Lor knockoutLOR, loricrinNKO, Nrf2 knockoutSC, stratum corneumSG, stratum granulosumTEWL, transepidermal water lossTS, tape-strippingWT, wild type

Identifiers

PMID35024686
PMCPMC8659797
OpenAlexW3207318497

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.