Evidence map›Paper›PMID 35024613›Full record

ArticleRSC medicinal chemistry2021

Investigating 3,3-diaryloxetanes as potential bioisosteres through matched molecular pair analysis.

Maryne A J Dubois, Rosemary A Croft, Yujie Ding, Chulho Choi, Dafydd R Owen, James A Bull, James J Mousseau

Open access · hybridAbstract read
In one paragraph

Article in RSC medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. LIDDIA: Language-based Intelligent Drug Discovery Agent.Proceedings of the Conference on Empirical Methods in Natural Language Processing. Conference on Empirical Methods in Natural Language Processing · 2025
    Article
  5. Article
  6. Applications of oxetanes in drug discovery and medicinal chemistry.European journal of medicinal chemistry · 2023
    Review
  7. Oxetanes in Drug Discovery Campaigns.Journal of medicinal chemistry · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Maryne A J DuboisDepartment of Chemistry, Molecular Sciences Research Hub, White City Campus, Imperial College London Wood Lane London W12 0BZ UK j.bull@imperial.ac.uk.
Rosemary A CroftDepartment of Chemistry, Molecular Sciences Research Hub, White City Campus, Imperial College London Wood Lane London W12 0BZ UK j.bull@imperial.ac.uk.
Yujie DingDepartment of Chemistry, Molecular Sciences Research Hub, White City Campus, Imperial College London Wood Lane London W12 0BZ UK j.bull@imperial.ac.uk.
Chulho ChoiMedicine Design, Pfizer Worldwide Research, Development and Medical 445 Eastern Point Rd. Groton CT 06340 USA james.mousseau@haldathera.com.
Dafydd R OwenPfizer Medicine Design 610 Main St Cambridge MA 02139 USA.
James A BullDepartment of Chemistry, Molecular Sciences Research Hub, White City Campus, Imperial College London Wood Lane London W12 0BZ UK j.bull@imperial.ac.uk.ORCID https://orcid.org/0000-0003-3993-5818
James J MousseauMedicine Design, Pfizer Worldwide Research, Development and Medical 445 Eastern Point Rd. Groton CT 06340 USA james.mousseau@haldathera.com.
Imperial College London · GBPfizer (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxetanes have received increasing interest in medicinal chemistry as attractive polar and low molecular weight motifs. The application of oxetanes as replacements for methylene, methyl,

Identifiers

PMID35024613
PMCPMC8672821
OpenAlexW3203208773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.