Evidence map›Paper›PMID 35024608›Full record

ArticleToxicon: X2022

Heterologous expression of four recombinant toxins from Panamanian scorpions of the genus

Marcos H Salazar, Herlinda Clement, Ligia L Corrales-García, Jairo Sánchez, John Cleghorn, Fernando Zamudio, Lourival D Possani, Hildaura Acosta, Gerardo Corzo

Open access · goldAbstract read
In one paragraph

Article in Toxicon: X, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Proteomic characterization ofThe journal of venomous animals and toxins including tropical diseases · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Marcos H SalazarCentro de Investigación e Información de Medicamentos y Tóxicos (CIIMET), Facultad de Medicina, Universidad de Panamá, Ciudad de Panamá, Panamá.
Herlinda ClementInstituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.
Ligia L Corrales-GarcíaInstituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.
Jairo SánchezCentro de Investigación e Información de Medicamentos y Tóxicos (CIIMET), Facultad de Medicina, Universidad de Panamá, Ciudad de Panamá, Panamá.
John CleghornCentro de Investigación e Información de Medicamentos y Tóxicos (CIIMET), Facultad de Medicina, Universidad de Panamá, Ciudad de Panamá, Panamá.
Fernando ZamudioInstituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.
Lourival D PossaniInstituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.
Hildaura AcostaCentro de Investigación e Información de Medicamentos y Tóxicos (CIIMET), Facultad de Medicina, Universidad de Panamá, Ciudad de Panamá, Panamá.
Gerardo CorzoInstituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.
Universidad de Panamá · PAUniversidad Nacional Autónoma de México · MXUniversidad de Antioquia · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe development of more effective antivenoms remains a necessity for countries where scorpionism is a public health problem. Also, the regionalization of antivenoms may be important for some countries with special scorpionism characteristics.

objectiveProduction of antibodies capable of neutralizing the lethal effect of the venom of three scorpion species from Panama.

methodsThe primary structures of two neurotoxins from

resultsThe antibodies produced under the reported immunization scheme show better neutralization (ED

conclusionThe information reported here shows the proof of concept for selecting recombinant immunogens with the ability to produce antibodies for neutralizing the lethal effects of the most important medical species of scorpions in Panama.

Indexed as

Animal venomCentruroidesProteomicsRecombinant proteinTityus

Identifiers

PMID35024608
PMCPMC8728522
OpenAlexW4200372397

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.