Evidence map›Paper›PMID 35024578›Full record

ArticleiScience2022

Drift compensation on electronic nose data for non-invasive diagnosis of prostate cancer by urine analysis.

Carmen Bax, Stefano Prudenza, Giulia Gaspari, Laura Capelli, Fabio Grizzi, Gianluigi Taverna

Open access · goldAbstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Accuracy of a new electronic nose for prostate cancer diagnosis in urine samples.International journal of urology : official journal of the Japanese Urological Association · 2022
    Trial
  3. Review
  4. Review
  5. Article
  6. Determination of Odor Air Quality Index (Molecules (Basel, Switzerland) · 2022
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Carmen BaxPolitecnico di Milano, Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", piazza Leonardo da Vinci 32, Milan 20133, Italy.
Stefano PrudenzaPolitecnico di Milano, Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", piazza Leonardo da Vinci 32, Milan 20133, Italy.
Giulia GaspariPolitecnico di Milano, Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", piazza Leonardo da Vinci 32, Milan 20133, Italy.
Laura CapelliPolitecnico di Milano, Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", piazza Leonardo da Vinci 32, Milan 20133, Italy.
Fabio GrizziDepartment of Immunology and Inflammation, IRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano, Milan 20089, Italy.
Gianluigi TavernaDepartment of Urology, Humanitas Mater Domini Hospital, Via Gerenzano, 2, Castellanza, 21053 Varese, Italy.
Politecnico di Milano · ITHumanitas Mater Domini · ITHumanitas University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diagnostic protocol for prostate cancer (KP) is affected by poor accuracy and high false-positive rate. The most promising innovative approach is based on urine analysis by electronic noses (ENs), highlighting a specific correlation between urine alteration and KP presence. Although EN could be exploited to develop non-invasive KP diagnostic tools, no study has already introduced EN into clinical practice, most probably because of drift issues that hinder EN scaling up from research objects to large-scale diagnostic devices. This study, proposing an EN for non-invasive KP detection, describes the data processing protocol applied to a urine headspace dataset acquired over 9 months, comprising 81 patients with KP and 41 controls, for compensating the drift. It proved effective in mitigating drift on 1-year-old sensors by restoring accuracy from 55% up to 80%, achieved by new sensors not subjected to drift. The model achieved, on double-blind validation, a balanced accuracy of 76.2% (CI

Indexed as

Biological sciencesBiotechnologyCancerChemical engineeringChemistryDiagnosticsDiagnostic technique in health technologyNatural sciences

Identifiers

PMID35024578
PMCPMC8725018
OpenAlexW4200302889

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.