ArticleNetwork neuroscience (Cambridge, Mass.)2021
The ascending arousal system promotes optimal performance through mesoscale network integration in a visuospatial attentional task.
Article in Network neuroscience (Cambridge, Mass.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Mapping Executive Function Performance Based on Resting-State EEG in Healthy Individuals: A Systematic and Mechanistic Review.Journal of clinical medicine · 2026Review
- Neuromodulatory influences on propagation of traveling waves along the unimodal-transmodal gradient.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
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- Locus coeruleus activation 'resets' hippocampal event representations and separates adjacent memories.bioRxiv : the preprint server for biology · 2025Article
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- Gaming expertise induces meso‑scale brain plasticity and efficiency mechanisms as revealed by whole-brain modeling.NeuroImage · 2024Article
- From pre-processing to advanced dynamic modeling of pupil data.Behavior research methods · 2024Article
- Neurophysiological patterns reflecting vulnerability to delirium subtypes: a resting-state EEG and event-related potential study.Brain communications · 2024Article
- Gaming expertise induces meso-scale brain plasticity and efficiency mechanisms as revealed by whole-brain modeling Gaming expertise, neuroplasticity and functional dynamics.bioRxiv : the preprint server for biology · 2023Article
- Impact of acute psychosocial stress on attentional control in humans. A study of evoked potentials and pupillary response.Neurobiology of stress · 2023Article
- Spontaneous variations in arousal modulate subsequent visual processing and local field potential dynamics in the ferret during quiet wakefulness.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Neuromodulatory control of complex adaptive dynamics in the brain.Interface focus · 2023Review
- Hierarchical functional system development supports executive function.Trends in cognitive sciences · 2023Review
- Arousal system stimulation and anesthetic state alter visuoparietal connectivity.Frontiers in systems neuroscience · 2023Article
- Parallel processing relies on a distributed, low-dimensional cortico-cerebellar architecture.Network neuroscience (Cambridge, Mass.) · 2023Article
- Structural connections between the noradrenergic and cholinergic system shape the dynamics of functional brain networks.NeuroImage · 2022Article
- Chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network.Science advances · 2022Article
- Brain-heart interactions in the neurobiology of consciousness.Current research in neurobiology · 2022Review
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Authors and funding
11 authors.
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Abstract
Previous research has shown that the autonomic nervous system provides essential constraints over ongoing cognitive function. However, there is currently a relative lack of direct empirical evidence for how this interaction manifests in the brain at the macroscale level. Here, we examine the role of ascending arousal and attentional load on large-scale network dynamics by combining pupillometry, functional MRI, and graph theoretical analysis to analyze data from a visual motion-tracking task with a parametric load manipulation. We found that attentional load effects were observable in measures of pupil diameter and in a set of brain regions that parametrically modulated their BOLD activity and mesoscale network-level integration. In addition, the regional patterns of network reconfiguration were correlated with the spatial distribution of the α2a adrenergic receptor. Our results further solidify the relationship between ascending noradrenergic activity, large-scale network integration, and cognitive task performance.
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