ArticleJACC. Basic to translational science2021
Abnormal Flow Conditions Promote Endocardial Fibroelastosis Via Endothelial-to-Mesenchymal Transition, Which Is Responsive to Losartan Treatment.
Article in JACC. Basic to translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 21 citations in OpenAlex.
- In Vitro Models to Study Fibroelastic Remodeling of the Endocardium in Congenital Heart Disease.Pediatric cardiology · 2026Article
- Imatinib Mesylate and Sirolimus Inhibit Vascular Fibroproliferative Remodeling in Pulmonary Vein Stenosis.Children (Basel, Switzerland) · 2026Article
- Cardiac mechanotransduction from development to disease.APL bioengineering · 2026Review
- Genetic drivers of congenital cardiac fibrosis.Communications biology · 2026Review
- Shear Stress Initiates Endothelial-to-Mesenchymal Transition in Endocardial Endothelial Cells.Annals of biomedical engineering · 2026Article
- Fibroelastic Remodelling of the Endocardium on the Right Side of the Heart: Endothelial-to-Mesenchymal Transition in Pulmonary Atresia With Intact Ventricular Septum.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2026Article
- Shear stress-induced CaBiological research · 2026Article
- Endothelial-to-mesenchymal transition in the central nervous system: A potential therapeutic target to combat age-related vascular fragility.The Journal of pharmacology and experimental therapeutics · 2025Review
- Endocardial Fibrosis Elastosis: Long-Standing Mystery and Promising Therapy.JACC. Basic to translational science · 2025Article
- Preclinical Assessment of Atorvastatin for Treatment of Endocardial Fibroelastosis.JACC. Basic to translational science · 2025Article
- Eliminating left ventricular outlet stenosis lowers the risk for endocardial fibroelastosis recurrence†.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- Left atrial wall shear stress correlates with fibrosis in patients with atrial fibrillation.Nature cardiovascular research · 2025Observational
- Nexilin in cardiomyopathy: unveiling its diverse roles with special focus on endocardial fibroelastosis.Heart failure reviews · 2024Review
- Endocardium in Hypoplastic Left Heart Syndrome: Implications from In Vitro Study.Journal of cardiovascular development and disease · 2022Article
- Review
- Endothelial-to-Mesenchymal Transition as Underlying Mechanism for the Formation of Double-Chambered Right Ventricle.Pediatric cardiology · 2022Article
- The value of cardiac magnetic resonance imaging in endocardial fibroelastosis.Frontiers in pediatrics · 2022Article
- Case report: Active clinical manifestation of endocardial fibroelastosis in adolescence in a patient with mitral and aortic obstruction-histologic presence of endothelial-to-mesenchymal transformation.Frontiers in cardiovascular medicine · 2022Article
- Growing With the Flow: Insights Into How Flow Mediates Endocardial Fibroelastosis.JACC. Basic to translational science · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endocardial fibroelastosis (EFE) is defined by fibrotic tissue on the endocardium and forms partly through aberrant endothelial-to-mesenchymal transition. However, the pathologic triggers are still unknown. In this study, we showed that abnormal flow induces EFE partly through endothelial-to-mesenchymal transition in a rodent model, and that losartan can abrogate EFE development. Furthermore, we translated our findings to human endocardial endothelial cells, and showed that laminar flow promotes the suppression of genes associated with mesenchymal differentiation. These findings emphasize the role of flow in promoting EFE in endocardial endothelial cells and provide a novel potential therapy to treat this highly morbid condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.