Evidence map›Paper›PMID 35024493›Full record

ArticleVeterinary and animal science2022

Pharmacokinetics and analytical determination of acyclovir in Asian elephant calves (

Siripat Khammesri, Chadarat Ampasavate, Darunee Hongwiset, Raktham Mektrirat, Siriluk Sangsrijan, Janine L Brown, Chatchote Thitaram

Open access · goldAbstract read
In one paragraph

Article in Veterinary and animal science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Siripat KhammesriCenter of Elephant and Wildlife Health and Research, Faculty of Veterinary Medicine, Chiang Mai University, Thailand.
Chadarat AmpasavateDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University Thailand.
Darunee HongwisetDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University Thailand.
Raktham MektriratDepartment of Veterinary Biosciences and Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Thailand.
Siriluk SangsrijanPharmacy Service Center, Faculty of Pharmacy, Chiang Mai University, Thailand.
Janine L BrownCenter of Elephant and Wildlife Health and Research, Faculty of Veterinary Medicine, Chiang Mai University, Thailand.
Chatchote ThitaramCenter of Elephant and Wildlife Health and Research, Faculty of Veterinary Medicine, Chiang Mai University, Thailand.
Chiang Mai University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A therapeutic regimen that includes antiviral drugs is critical for the survival of Asian elephant (

Indexed as

AcyclovirAsian elephantAUC0-inf, Total area under the plasma concentration-time curve from time zero to infinityAUC0-t, Total area under the plasma concentration-time curve from time 0–48hBioavailabilityCl, Total clearanceCmax, Peak plasma concentration%CV, Mean precisionEEHV, Elephantendotheliotropic herpesvirusesEEHV-HD, Elephant endotheliotropic herpesvirus hemorrhagic diseaseEHV, Equid alphaherpesvirusElephant endotheliotropic herpesvirus (EEHV)F, BioavailabilityHSV, Herpes simplex virusIV, Intravenous administrationKel, Elimination rate constantLC-MS/MS, Liquid chromatography-tandem mass spectrometryLLOQ, Lower limit of quantitationMAT, Mean absorption timeMRM, Multiple reaction monitoringMRT, Mean residence timem/z, Mass-to-charge ratioPharmacokineticsPO, Oral administrationQC, Quality controlr2, Coefficients of determinationS/N, Signal to noise ratioT1/2, Elimination half-lifeTmax, Time to reach peak plasmaVd(ss), Steady-state volume of distribution

Identifiers

PMID35024493
PMCPMC8724961
OpenAlexW4200542302

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.