Evidence map›Paper›PMID 35024478›Full record

ArticleSynthetic and systems biotechnology2022

Improved l-phenylglycine synthesis by introducing an engineered cofactor self-sufficient system.

Pengchao Wang, Xiwen Zhang, Yucheng Tao, Xubing Lv, Shengjie Cheng, Chengwei Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synthetic and systems biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Pengchao WangSchool of Life Science, Northeast Forestry University, Harbin, 150040, Heilongjiang, PR China.
Xiwen ZhangSchool of Life Science, Northeast Forestry University, Harbin, 150040, Heilongjiang, PR China.
Yucheng TaoSchool of Life Science, Northeast Forestry University, Harbin, 150040, Heilongjiang, PR China.
Xubing LvSchool of Life Science, Northeast Forestry University, Harbin, 150040, Heilongjiang, PR China.
Shengjie ChengSchool of Life Science, Northeast Forestry University, Harbin, 150040, Heilongjiang, PR China.
Chengwei LiuSchool of Life Science, Northeast Forestry University, Harbin, 150040, Heilongjiang, PR China.
Northeast Forestry University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

l-phenylglycine (L-phg) is a valuable non-proteinogenic amino acid used as a precursor to β-lactam antibiotics, antitumor agent taxol and many other pharmaceuticals. L-phg synthesis through microbial bioconversion allows for high enantioselectivity and sustainable production, which will be of great commercial and environmental value compared with organic synthesis methods. In this work, an L-phg synthesis pathway was built in

Indexed as

Hydroxymandelate synthaseL-phenylglycineProtein scaffoldSelf-sufficientWhole-cell biocatalyst

Identifiers

PMID35024478
PMCPMC8715069
OpenAlexW4200469792

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.