ArticleAnimal nutrition (Zhongguo xu mu shou yi xue hui)2022
Heat stress-induced mucosal barrier dysfunction is potentially associated with gut microbiota dysbiosis in pigs.
Article in Animal nutrition (Zhongguo xu mu shou yi xue hui), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 83 citations in OpenAlex.
- In-depth examination of the zinc-mitigation of the molecular effects of heat stress-induced intestinal damage in broilers.Poultry science · 2026Article
- Oxidative stress in pigs and opportunities with selenium-containing amino acids.Stress biology · 2026Review
- Effects of Pig Weaning Weight and Sex on Growth Performance, Fecal Score, and Blood Antioxidant Capacity in Early Nursery Period.Animals : an open access journal from MDPI · 2026Article
- Nuclear Magnetic Resonance-Based Urinary Metabolic Profiling for Assessing Heat Stress-Related Incident Kidney Injury in Health-Care Workers.GeoHealth · 2026Article
- Pyrroloquinoline quinone protects heat-stressed porcine oocytes and improves early embryonic development via maintaining mitochondrial integrity and redox homeostasis.Biology direct · 2026Article
- Revealing growth performance in weaned Tibetan pigs along with gut microbial diversity and oxidative status under the impact of ambient temperature.BMC microbiology · 2026Article
- Alleviation of heat stress-induced microbial dysbiosis in pigs through dietary supplementation with vitamins and trace elements.Animal microbiome · 2026Article
- Investigating alterations associated with heat stress and the recovery of the intestinal barrier using IPEC-J2 as an intestinal epithelial porcine cell model.Scientific reports · 2026Article
- Nutrigenomic Potentials of Phytobiotics Against Heat Stress and Allied Afflictions in Livestock Species-An In Silico Supported Review.Food science & nutrition · 2026Review
- Intestinal Development in Wuzhishan Pigs at Different Growth Phases: Insights from Microbiome and Metabolomics.Animals : an open access journal from MDPI · 2026Article
- Data-driven enterosignatures link gut microbiome reorganization to heat stress responses in lactating sows.Frontiers in microbiology · 2026Article
- Heat stress-induced gut dysbiosis and multi-organ injury: mechanisms and therapeutic modulation.Frontiers in cellular and infection microbiology · 2026Review
- Gut Microbiome and Metabolome Signatures Associated with Heat Tolerance in Dairy Cows.Microorganisms · 2025Article
- Connecting Molecular Characteristics of Intrauterine Growth-Retarded Piglets to Targeted Nutritional Interventions: A Review.Animals : an open access journal from MDPI · 2025Review
- Co-occurring microbial guilds in pig fecal microbiota: key drivers and effects on host performance.Genetics, selection, evolution : GSE · 2025Article
- Hydroxy-Selenomethionine Supplementation During Gestation and Lactation Improve Reproduction of Sows by Enhancing the Antioxidant Capacity and Immunity Under Heat Stress Conditions.Antioxidants (Basel, Switzerland) · 2025Article
- Effects of dietary mineral level and creep feed provision on lactating sows during heat stress.Tropical animal health and production · 2025Article
- Heat Stress in Growing-Finishing Pigs: Effects of Low Protein with Increased Crystalline Amino Acids on Growth, Gut Health, Antioxidant Status and Microbiome.Animals : an open access journal from MDPI · 2025Article
- Extracellular matrix gene set and microRNA network in intestinal ischemia-reperfusion injury: Insights from RNA sequencing for diagnosis and therapy.World journal of gastrointestinal surgery · 2025Review
- Dietary low levels ofFrontiers in microbiology · 2025Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat stress (HS) can be detrimental to the gut health of swine. Many negative outcomes induced by HS are increasingly recognized as including modulation of intestinal microbiota. In turn, the intestinal microbiota is a unique ecosystem playing a critical role in mediating the host stress response. Therefore, we aimed to characterize gut microbiota of pigs' exposure to short-term HS, to explore a possible link between the intestinal microbiota and HS-related changes, including serum cytokines, oxidation status, and intestinal epithelial barrier function. Our findings showed that HS led to intestinal morphological and integrity changes (villus height, serum diamine oxidase [DAO], serum D-lactate and the relative expressions of tight junction proteins), reduction of serum cytokines (interleukin [IL]-8, IL-12, interferon-gamma [IFN-γ]), and antioxidant activity (higher glutathione [GSH] and malondialdehyde [MDA] content, and lower superoxide dismutase [SOD]). Also, 16S rRNA sequencing analysis revealed that although there was no difference in microbial α-diversity, some HS-associated composition differences were revealed in the ileum and cecum, which partly led to an imbalance in the production of short-chain fatty acids including propionate acid and valerate acid. Relevance networks revealed that HS-derived changes in bacterial genera and microbial metabolites, such as
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.