Evidence map›Paper›PMID 35024423›Full record

ArticleSSM - population health2022

Higher educational attainment is associated with longer telomeres in midlife: Evidence from sibling comparisons in the UK Biobank.

Vikesh Amin, Jason M Fletcher, Zhongxuan Sun, Qiongshi Lu

Abstract read
In one paragraph

Article in SSM - population health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vikesh AminCentral Michigan University, Mt Pleasant, MI, 48859, United States.
Jason M FletcherUniversity of Wisconsin-Madison, NBER, and IZA, United States.
Zhongxuan SunUniversity of Wisconsin-Madison, United States.
Qiongshi LuUniversity of Wisconsin-Madison, United States.

Funding

Statistical Data Enclave CoreP30AG017266 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Michal Engelman · 1999 to 2026
$17.0M
The Importance of Place in Determining Health and Mortality at Older AgesR01AG060109 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI FLETCHER, JASON MICHAEL, PALLONI, ALBERTO B. · 2018 to 2022
$2.2M
Genes, Education, and Gene-Education Interactions in Obesity and Mental HealthR01HD094011 · NICHD · CENTRAL MICHIGAN UNIVERSITY · PI AMIN, VIKESH · 2018 to 2020
$955k
Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NIA NIH HHS P30 AG017266NIA NIH HHS R01 AG060109NICHD NIH HHS R01 HD094011
6 · The paper itself

Abstract

Prior studies have established that higher educational attainment is associated with a longer telomere length (TL), a marker of cellular aging. However, it is unclear whether extant associations are causal, since they are likely confounded by unobserved genetic, early-life and family background factors that are correlated with education and TL. We leverage sibling differences in TL, education and measured genetics (polygenic scores for educational attainment and TL) to estimate associations between educational attainment and TL in midlife for European ancestry individuals in the UK Biobank, while controlling for unobserved confounders shared by siblings. After controlling for genetics and shared background between siblings, we find suggestive evidence that high school graduates have longer telomeres than high school dropouts, but we find no differences in TL between high school dropouts and college graduates.

Indexed as

Causal inferenceCellular agingEducationTelomere length

Identifiers

PMID35024423
PMCPMC8728101

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.