Evidence map›Paper›PMID 35024311›Full record

ArticleActa pharmaceutica Sinica. B2021

Bile acid homeostasis in female mice deficient in

Daniel Rizzolo, Bo Kong, Rulaiha E Taylor, Anita Brinker, Michael Goedken, Brian Buckley, Grace L Guo

Open access · diamondAbstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.

  1. Pooled it
  2. Role of Bile Acid Receptors in Non-Infectious Diarrhea: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Daniel RizzoloDepartment of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
Bo KongDepartment of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
Rulaiha E TaylorDepartment of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
Anita BrinkerEnvironmental and Occupational Health Institute, Rutgers University, Piscataway, NJ 08854, USA.
Michael GoedkenOffice of Research and Economic Development, Research Pathology Services, Rutgers University, Piscataway, NJ 08854, USA.
Brian BuckleyDepartment of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
Grace L GuoDepartment of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
Rutgers, The State University of New Jersey · US

Funding

TRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4M
Gut-liver crosstalk by FGF15/19 in regulating xenobiotic nuclear receptor activationR01GM135258 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI GUO, GRACE L · 2020 to 2023
$1.4M
BLRD VA I01 BX002741NIEHS NIH HHS T32 ES007148NIGMS NIH HHS R01 GM135258
6 · The paper itself

Abstract

Bile acids (BAs) are amphipathic molecules important for metabolism of cholesterol, absorption of lipids and lipid soluble vitamins, bile flow, and regulation of gut microbiome. There are over 30 different BA species known to exist in humans and mice, which are endogenous modulators of at least 6 different membrane or nuclear receptors. This diversity of ligands and receptors play important roles in health and disease; however, the full functions of each individual BA

Indexed as

ALP, alkaline phosphataseALT, alanine aminotransferaseASBT, apical sodium-dependent BA transporterAST, aspartate transaminaseBA, bile acidBile acidsBSEP, bile salt export pumpCA, cholic acidCDCA, chenodeoxycholic acidCYP27A1CYP27A1, sterol 27-hydroxylaseCYP2C70, cytochrome P450 2C70CYP7A1CYP7A1, cholesterol 7α-hydroxylaseCYP7B1, 25-hydroxycholesterol 7-alpha-hydroxylaseCYP8B1, sterol 12α-hydroxylaseDCA, deoxycholic acidDKO, double knockoutFarnesoid X receptorFemaleFibroblast growth factor 15FXR, farnesoid X receptorIBABP, intestinal BA-binding proteinLCA, lithocholic acidNTCP, sodium taurocholate cotransporting polypeptideOATP, organic anion transportersOSTα/β, organic solute transporters alpha and betaWT, wild typeβMCA, beta muricholic acid

Identifiers

PMID35024311
PMCPMC8727763
OpenAlexW3164100141

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.