ArticleActa pharmaceutica Sinica. B2021
Proteomics and metabolic phenotyping define principal roles for the aryl hydrocarbon receptor in mouse liver.
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Article in Acta pharmaceutica Sinica. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17citing papers in PubMed, 1 pooled it
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Studying the Impact of Persistent Organic Pollutants Exposure on Human Health by Proteomic Analysis: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Review
- Whole-Body Knockout of the AhR (Aryl Hydrocarbon Receptor) Ameliorates Atherosclerosis Due to Altered Lipid Metabolism-Brief Report.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- 3,3'-Dichlorobiphenyl (PCB 11) alters the hepatic expression of cytochrome P450 enzymes in the liver of mouse dams exposed orally during pregnancy and lactation.Archives of toxicology · 2026Article
- Multi-omics analysis of key lipid metabolism-related genes involved in the anti-hepatocellular carcinoma effect of dihydroartemisinin.Discover oncology · 2026Article
- AHR Deficiency Exacerbates Hepatic Cholesterol Accumulation via Inhibiting Bile Acid Synthesis in MAFLD Rats.International journal of molecular sciences · 2025Article
- Article
- Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive androstane receptor: primary and secondary gene responses with links to disease progression.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Exploring the therapeutic potential of garlic in alcoholic liver disease: a network pharmacology and experimental validation study.Genes & nutrition · 2024Article
- Multiomics Analysis of PCB126's Effect on a Mouse Chronic-Binge Alcohol Feeding Model.Environmental health perspectives · 2024Article
- Type 3 secretion system induced leukotriene B4 synthesis by leukocytes is actively inhibited by Yersinia pestis to evade early immune recognition.PLoS pathogens · 2024Article
- Article
- Disruption of the mouse liver epitranscriptome by long-term aroclor 1260 exposure.Environmental toxicology and pharmacology · 2023Article
- Polychlorinated biphenyls alter hepatic m6A mRNA methylation in a mouse model of environmental liver disease.Environmental research · 2023Article
- The environmental pollutant, polychlorinated biphenyl 126, alters liver function in a rodent model of alcohol-associated liver disease.Alcohol, clinical & experimental research · 2023Article
- Aryl Hydrocarbon Receptor (AhR)-Mediated Signaling in iPSC-Derived Human Motor Neurons.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Biological Mechanisms and Related Natural Inhibitors of CD36 in Nonalcoholic Fatty Liver.Drug design, development and therapy · 2022Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 3 countries.
Jian JinDepartment of Pharmacology & Toxicology, the University of Louisville School of Medicine, Louisville, KY 40202, USA.
Banrida WahlangDivision of Gastroenterology, Hepatology & Nutrition, Department of Medicine, the University of Louisville School of Medicine, Louisville, KY 40202, USA.
Monika ThapaDepartment of Biochemistry and Molecular Genetics, the University of Louisville School of Medicine, Louisville, KY 40202, USA.
Kimberly Z HeadDivision of Gastroenterology, Hepatology & Nutrition, Department of Medicine, the University of Louisville School of Medicine, Louisville, KY 40202, USA.
Josiah E HardestyDivision of Gastroenterology, Hepatology & Nutrition, Department of Medicine, the University of Louisville School of Medicine, Louisville, KY 40202, USA.
Sudhir SrivastavaDepartment of Bioinformatics and Biostatistics, the School of Public Health and Information Sciences, the University of Louisville, Louisville, KY 40202, USA.
Michael L MerchantThe Center for Integrative Environmental Health Sciences, University of Louisville, Louisville, KY 40202, USA.
Shesh N RaiSuperfund Research Center, the University of Louisville, Louisville, KY 40202, USA.
Russell A ProughDepartment of Biochemistry and Molecular Genetics, the University of Louisville School of Medicine, Louisville, KY 40202, USA.
Matthew C CaveDepartment of Pharmacology & Toxicology, the University of Louisville School of Medicine, Louisville, KY 40202, USA.
University of Louisville · USIndian Agricultural Statistics Research Institute · IN
Funding
Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ZHANG, XIANG · 2016 to 2025
$24.1MSuperfund Training CoreP42ES023716 · NIEHS · UNIVERSITY OF LOUISVILLE · PI HEIN, DAVID W · 2017 to 2025
$18.1MThe Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN · 2016 to 2026
$17.9MUniversity of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Amanda Jo LeBlanc · 2020 to 2026
$10.0MUOFL ENVIRONMENTAL HEALTH SCIENCES TRAINING PROGRAMT32ES011564 · NIEHS · UNIVERSITY OF LOUISVILLE · PI David W Hein, John Pierce Wise · 2004 to 2026
$7.1MEnvironmental Liver DiseaseR35ES028373 · NIEHS · UNIVERSITY OF LOUISVILLE · PI CAVE, MATTHEW C · 2017 to 2024
$4.0MExposome and Precision Medicine in NAFLDR01ES032189 · NIEHS · UNIVERSITY OF LOUISVILLE · PI CAVE, MATTHEW C · 2020 to 2022
$1.9Mm6A Epitranscriptomics in Toxicant Associated SteatohepatitisR21ES031510 · NIEHS · UNIVERSITY OF LOUISVILLE · PI CAVE, MATTHEW C, KLINGE, CAROLYN M. · 2020 to 2021
$546kRvD1-FPR2 signaling ameliorates alcoholic liver diseaseF32AA027950 · NIAAA · UNIVERSITY OF LOUISVILLE · PI HARDESTY, JOSIAH E · 2020 to 2022
$164kPolychlorinated biphenyls act through EGFR to worsen NAFLDF31ES028982 · NIEHS · UNIVERSITY OF LOUISVILLE · PI HARDESTY, JOSIAH E · 2017 to 2018
$43kNIAAA NIH HHS F32 AA027950NIAAA NIH HHS L30 AA027913NIAAA NIH HHS P50 AA024337NIEHS NIH HHS F31 ES028982NIEHS NIH HHS P30 ES030283NIEHS NIH HHS P42 ES023716NIEHS NIH HHS R01 ES032189NIEHS NIH HHS R21 ES031510NIEHS NIH HHS R35 ES028373NIEHS NIH HHS T32 ES011564NIGMS NIH HHS P20 GM113226
Abstract
Dioxin-like molecules have been associated with endocrine disruption and liver disease. To better understand aryl hydrocarbon receptor (AHR) biology, metabolic phenotyping and liver proteomics were performed in mice following ligand-activation or whole-body genetic ablation of this receptor. Male wild type (WT) and
Indexed as
AHRAHR, aryl hydrocarbon receptorALT, alanine transaminaseANOVA, analysis of varianceAST, aspartate transaminaseAUC, area under the curveCAR, constitutive androstane receptorCD36, cluster of differentiation 36CYP, cytochrome P450Endocrine disruptionEnvironmental liver diseaseEPF, enrichment by protein functionFDR, false discovery rateFGF21, fibroblast growth factor 21GCR, glucocorticoid receptorGO, gene ontologyHDL, high-density lipoproteinH&E, hematoxylin-eosinHFD, high fat dietIGF1, insulin-like growth factor 1IL-6, interleukin 6IPF, interaction by protein functionLDL, low-density lipoproteinMCP-1, monocyte chemoattractant protein-1miR, microRNAMUP, major urinary proteinNAFLD, non-alcoholic fatty liver diseaseNFKBIA, nuclear factor kappa-inhibitor alphanHDLc, non-HDL cholesterolNonalcoholic fatty liver diseasePAI-1, plasminogen activator inhibitor-1PCB126PCB, polychlorinated biphenylPerilipin-2PheromonesPLIN2, perilipin-2PNPLA3, patatin-like phospholipase domain-containing protein 3PPARα, peroxisome proliferator-activated receptor alphaPXR, pregnane-xenobiotic receptorSGK1, serum/glucocorticoid regulated kinaseTAFLD, toxicant-associated fatty liver diseaseTASH, toxicant-associated steatohepatitisTAT, tyrosine aminotransferaseTMT, tandem mass tagVLDL, very low-density lipoproteinWT, wild typeZFP125, zinc finger protein 125
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