ArticleJournal of advanced research2021
A value-added application of eugenol as acaricidal agent: The mechanism of action and the safety evaluation.
Article in Journal of advanced research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Licochalcone A as a Potential Anti-Biomolecules · 2026Article
- The safety and efficacy of topical clove oil for the treatment of naturally occurringFrontiers in veterinary science · 2026Article
- Synthesis and bioactivity of tetrahydrothiopyran derivatives as potential acaricides against Psoroptes cuniculi.Molecular diversity · 2025Article
- Chemical composition and acaricidal properties of essential oils from Cinnamomum mollifolium, Eucalyptus globulus, and Pimenta dioica against Hyalomma rufipes (Acari: Ixodidae).BMC veterinary research · 2025Article
- Physiological and molecular responses of house fly (Musca domestica L.) to clove flower bud extracts.Scientific reports · 2025Article
- Potential of Eugenol for Eco-friendly Control of Aedes albopictus (Diptera: Culicidae) in an Integrated Model with Non-target Organism.Neotropical entomology · 2025Article
- Evaluating the multifaceted bioactivity ofTurkish journal of biology = Turk biyoloji dergisi · 2025Article
- Comparative efficacy of eugenol, eugenol nanoemulsion, and metronidazole againstOpen veterinary journal · 2024Article
- Anticoccidial activity of a botanical natural product based on eucalyptus, apigenin and eugenol against Eimeria tenella in broiler chickens.Parasites & vectors · 2024Article
- Protective role of Eugenol against the destructive effects of lead on conditioned fear memory in male rats with post-traumatic stress disorder-related behavioral traits.IBRO neuroscience reports · 2024Article
- Review
- Article
- Natural Products as Mite Control Agents in Animals: A Review.Molecules (Basel, Switzerland) · 2023Review
- Biological Activity of Hybrid Molecules Based on Major Constituents ofLife (Basel, Switzerland) · 2023Article
- Essential Oils againstMolecules (Basel, Switzerland) · 2022Review
- High value-added application of a renewable bioresource as acaricide: Investigation the mechanism of action of scoparone againstJournal of advanced research · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Eugenol is a major component of essential oils of several plants, it exhibits significant antiparasitic and acaricidal activities, yet its molecular targets remain unknown. Objectives: We aimed to systematically investigate the mechanism of action and the potential targets of eugenol against Methods: Using RNA-Seq analysis, surface plasmon resonance analysis and RNA interference assay, the mode of action of eugenol against Results: Eugenol inhibited complex I activity of the mitochondrial respiratory chain in the oxidative phosphorylation pathway by binding to NADH dehydrogenase chain 2 and resulted in the death of mites. The inhibition rates were 37.89% for 50 μg/mL and 60.26% for 100 μg/mL, respectively. Further experiments indicated that the difference in the complex I sequence between insects and mammals led to the different affinity of eugenol to specific peptide, resulting in species specificity. Eugenol exhibited significant inhibitory effects against the mitochondrial membrane potential and complex I in Conclusion: This is the first report on acaricidal eugenol targeting complex I of the mitochondrial respiratory chain. This work lays the foundation for the development of eugenol as an environmentally alternative acaricidal agent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.