ArticleJournal of advanced research2021
Hinokitiol chelates intracellular iron to retard fungal growth by disturbing mitochondrial respiration.
Article in Journal of advanced research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 63 citations in OpenAlex.
- Novel Hinokitiol-Based Ester/Sulfonate Derivatives Containing Diverse Heterocycles as Potential Fungicides and Nematicides.Chemistry & biodiversity · 2026Article
- Enhanced Pepper Resistance toPlant direct · 2026Article
- Study on the mechanism of hinokitiol in inhibiting the biofilm activity ofFrontiers in microbiology · 2026Article
- Low Wall Shear Stress Promotes Atheroma via Arterial Iron Accumulation.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- TCMD: A High-Throughput and Rapid Method for Screening Antimicrobial Ingredients from Renewable Bio-Based Resources.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Therapeutic potential of synthetic and natural iron chelators against ferroptosis.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Article
- Nestin Regulates Autophagy-Dependent Ferroptosis Mediated Skeletal Muscle Atrophy by Ubiquitinating MAP 1LC3B.Journal of cachexia, sarcopenia and muscle · 2025Article
- Cinnamaldehyde triggers cell wall remodeling and enhances macrophage-mediated phagocytic clearance ofFrontiers in cellular and infection microbiology · 2025Article
- Integrating ensemble machine learning and multi-omics approaches to identify Dp44mT as a novel anti-Frontiers in pharmacology · 2025Article
- Exploring the therapeutic potential of medicinal plants and their active principles in dental care: A comprehensive review.Heliyon · 2024Review
- Baicalin promotes β-1,3-glucan exposure inFrontiers in cellular and infection microbiology · 2024Article
- Inhibitory effects of hinokitiol on the development and pathogenicity of Colletotrichum gloeosporioides.World journal of microbiology & biotechnology · 2023Article
- Antifungal mechanism of volatile compounds emitted bymSphere · 2023Article
- Current and Potential Applications of Monoterpenes and Their Derivatives in Oral Health Care.Molecules (Basel, Switzerland) · 2023Review
- Review
- Mycobacterium tuberculosis hijacks host TRIM21- and NCOA4-dependent ferritinophagy to enhance intracellular growth.The Journal of clinical investigation · 2023Article
- Hinokitiol inhibitsFrontiers in microbiology · 2023Article
- 2Microbiology spectrum · 2022Article
- Selective Metal Chelation by a Thiosemicarbazone Derivative Interferes with Mitochondrial Respiration and Ribosome Biogenesis in Candida albicans.Microbiology spectrum · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The increasing morbidity of fungal infections and the prevalence of drug resistance highlighted the discovery of novel antifungal agents and investigation of their modes of action. Iron chelators have been used to treat superficial fungal infections or potentiate the efficacy of certain antifungal drugs. Hinokitiol exhibits potent antifungal activity and iron-chelating ability. However, their relationships have not been established. Objectives: This study aims to explore the selectivity of hinokitiol against fungal cells and mammalian cells and determine the role of iron-chelating for the antifungal activity of hinokitiol. Methods: Iron probe FeRhonox-1 was used to determine intracellular Fe Results: Hinokitiol was effective against a panel of Conclusions: These findings suggested the potential application of hinokitiol as an iron chelator to treat fungal infections.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.