ArticleMultiple sclerosis journal - experimental, translational and clinical
Usefulness of two-dimensional measurements for the evaluation of brain volume and disability in multiple sclerosis.
Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.
- Predictors of multiple sclerosis progression: A systematic review of conventional magnetic resonance imaging studies.PloS one · 2024Pooled it
- Neuroimaging markers and disability scales in multiple sclerosis: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Does Vitamin D Supplementation Slow Brain Volume Loss in Multiple Sclerosis? A 4-Year Observational Study.Nutrients · 2025Observational
- Multiple Sclerosis and Seizures: Clinical, Diagnostic and Therapeutic Correlations.Brain and behavior · 2025Article
- Differences in Brain Atrophy Pattern between People with Multiple Sclerosis and Systemic Diseases with Central Nervous System Involvement Based on Two-Dimensional Linear Measures.Journal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTwo-dimensional (2D) measures have been proposed as potential proxies for whole-brain volume in multiple sclerosis (MS).
objectiveTo verify whether 2D measurements by routine MRI are useful in predicting brain volume or disability in MS.
methodsIn this cross-sectional analysis, eighty-five consecutive Japanese MS patients-relapsing-remitting MS (81%) and progressive MS (19%)-underwent 1.5 Tesla T1-weighted 3D MRI examinations to measure whole-brain and grey matter volume. 2D measurements, namely, third ventricle width, lateral ventricle width (LVW), brain width, bicaudate ratio, and corpus callosum index (CCI), were obtained from each scan. Correlations between 2D measurements and 3D measurements, the Expanded Disability Status Scale (EDSS), or processing speed were analysed.
resultsThe third and lateral ventricle widths were well-correlated with the whole-brain volume (
conclusionVentricle width correlated well with brain volumes, while the CCI correlated well with age-independent (i.e. disease-induced) disability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.