ReviewJournal of blood medicine2022
DIC in Pregnancy - Pathophysiology, Clinical Characteristics, Diagnostic Scores, and Treatments.
Review in Journal of blood medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024: part 4-trauma, burn, obstetrics, acute pancreatitis/liver failure, and others.International journal of hematology · 2025Guideline
- COVID-19 in pregnant women: a systematic review and meta-analysis on the risk and prevalence of pregnancy loss.Human reproduction update · 2024Pooled it
- Disseminated intravascular coagulation in pregnancy: insights from an international collaborative registry.Journal of thrombosis and haemostasis : JTH · 2026Article
- The pathophysiology of pre-eclampsia.Nature reviews. Nephrology · 2026Review
- From Adaptive Resilience to Catastrophic Systems Collapse: Endothelial Entropy, Ferroptotic Propagation, and the Maternal Point of No Return in Emergency Peripartum Hysterectomy.International journal of molecular sciences · 2026Review
- PAD Score: A Clinical Prediction Tool for Disseminated Intravascular Coagulation in Placental Abruption.Journal of clinical medicine · 2026Article
- Management of Amniotic Fluid Embolism (AFE) using anticoagulation-free ECMO.Zeitschrift fur Geburtshilfe und Neonatologie · 2026Article
- The value of coagulation index in thromboelastography for predicting early pregnancy loss in in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles.Scientific reports · 2026Article
- Fulminant disseminated intravascular coagulation following marsupialization of a Bartholin gland abscess: a case report.Case reports in women's health · 2026Article
- Left ovarian vein thrombosis suspected during cesarean section and confirmed postoperatively: a case report and review of the literature.BMC pregnancy and childbirth · 2026Review
- Atypical amniotic fluid embolism presenting with isolated coagulopathy: a case report.BMC pregnancy and childbirth · 2026Article
- Vertical versus transverse abdominal incision in placental abruption: a propensity score-matched study on the trade-off between speed and maternal-neonatal safety.Frontiers in medicine · 2026Article
- Liver function disorders in pregnancy: physiology or pathology?Przeglad gastroenterologiczny · 2026Review
- New approaches in the haemostatic management of postpartum haemorrhage.BMJ medicine · 2026Review
- Pathological features, clinical monitoring, and perinatal outcomes of placental thickening: a report of two cases.Gynecology and pelvic medicine · 2026Article
- Severe maternal morbidity and re-hospitalisation in the first postpartum year within Canada, 2008-2020: a population-based retrospective cohort study.BMJ public health · 2026Article
- Spontaneous Hepatic Hemangioma Rupture in a Normotensive Twin Pregnancy: A Case Report.Cureus · 2025Article
- Article
- Diagnostic and Prognostic Evaluation of Disseminated Intravascular Coagulation Using the Disseminated Intravascular Coagulation Index.Journal of clinical medicine · 2025Article
- Multicenter Retrospective Evaluation of the Chinese Expert Consensus Scoring System for the Diagnosis of Obstetrical DIC.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2025Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obstetrical hemorrhage and especially DIC (disseminated intravascular coagulation) is a leading cause for maternal mortality across the globe, often secondary to underlying maternal and/or fetal complications including placental abruption, amniotic fluid embolism, HELLP syndrome (hemolysis, elevated liver enzymes and low platelets), retained stillbirth and acute fatty liver of pregnancy. Various obstetrical disorders can present with DIC as a complication; thus, increased awareness is key to diagnosing the condition. DIC patients can present to clinicians who may not be experienced in a variety of aspects of thrombosis and hemostasis. Hence, DIC diagnosis is often only entertained when the patient already developed uncontrollable bleeding or multi-organ failure, all of which represent unsalvageable scenarios. Beyond the clinical presentations, the main issue with DIC diagnosis is in relation to coagulation test abnormalities. It is widely believed that in DIC, patients will have prolonged prothrombin time (PT) and partial thromboplastin time (PTT), thrombocytopenia, low fibrinogen, and raised D-dimers. Diagnosis of DIC can be elusive during pregnancy and requires vigilance and knowledge of the physiologic changes during pregnancy. It can be facilitated by using a pregnancy specific DIC score including three components: 1) fibrinogen concentrations; 2) the PT difference - relating to the difference in PT result between the patient's plasma and the laboratory control; and 3) platelet count. At a cutoff of ≥26 points, the pregnancy specific DIC score has 88% sensitivity, 96% specificity, a positive likelihood ratio (LR) of 22, and a negative LR of 0.125. Management of DIC during pregnancy requires a prompt attention to the underlying condition leading to this complication, including the delivery of the patient, and correction of the hemostatic problem that can be guided by point of care testing adjusted for pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.