ArticleInternational journal of general medicine2022
Serum Anion Gap is Associated with Risk of All-Cause Mortality in Critically Ill Patients with Acute Myocardial Infarction.
Article in International journal of general medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-Analysis of the Effects of Recombinant Human Brain Natriuretic Peptides on Left Ventricular Remodeling in Patients with Acute Myocardial Infarction.Computational and mathematical methods in medicine · 2022Pooled it
- Predictive Value of 48-hour Anion Gap Fluctuations in ICU Patients with Acute Kidney Injury: An Analysis based on MIMIC Database.Current pharmaceutical design · 2026Article
- Predicting ICU mortality in patients with abdominal aortic aneurysm: a nomogram based on MIMIC-IV and eICU-CRD.International journal of medical sciences · 2026Article
- Non-linear association between anion gap and 28-day mortality in critically ill patients with COVID-19: a cohort study from MIMIC IV database.Journal of thoracic disease · 2025Article
- The association between anion gap and prognosis in patients myocardial infarction with congestive heart failure: a retrospective analysis of the MIMIC-IV database.International journal of emergency medicine · 2025Article
- Article
- Association between serum anion gap and 28-day mortality in critically ill patients with infective endocarditis: a retrospective cohort study from MIMIC IV database.BMC cardiovascular disorders · 2024Article
- Association of alactic base excess with in-hospital mortality in patients with acute myocardial infarction: a retrospective cohort study.BMC cardiovascular disorders · 2024Article
- Association between the anion gap and mortality in critically ill patients with influenza: A cohort study.Heliyon · 2024Article
- Association between Albumin-Corrected Anion Gap and Mortality in Patients with Cardiogenic Shock.Reviews in cardiovascular medicine · 2024Article
- Association between serum anion gap and risk of in-hospital mortality in patients with acute heart failure.Scientific reports · 2024Article
- Albumin corrected anion gap for predicting in-hospital death among patients with acute myocardial infarction: A retrospective cohort study.Clinics (Sao Paulo, Brazil) · 2024Article
- The association between serum anion gap and acute kidney injury after coronary artery bypass grafting in patients with acute coronary syndrome.BMC cardiovascular disorders · 2023Article
- Serum anion gap is associated with mortality in intensive care unit patients with diastolic heart failure.Scientific reports · 2023Article
- Association between albumin corrected anion gap and 30-day all-cause mortality of critically ill patients with acute myocardial infarction: a retrospective analysis based on the MIMIC-IV database.BMC cardiovascular disorders · 2023Article
- Simplified acute physiology score III is excellent for predicting in-hospital mortality in coronary care unit patients with acute myocardial infarction: A retrospective study.Frontiers in cardiovascular medicine · 2022Article
- Base excess is associated with the risk of all-cause mortality in critically ill patients with acute myocardial infarction.Frontiers in cardiovascular medicine · 2022Article
- Association Between High Serum Anion Gap and All-Cause Mortality in Non-Traumatic Subarachnoid Hemorrhage: A Retrospective Analysis of the MIMIC-IV Database.Frontiers in neurology · 2022Article
- The Anion Gap and Mortality in Critically Ill Patients with Hip Fractures.Contrast media & molecular imaging · 2022Article
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7 authors.
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Abstract
purposeAnion gap (AG) is a valuable and easily obtained clinical tool for differentially diagnosis of acid-base disorders. Current understanding of the prognostic impact of AG on mortality after acute myocardial infarction (AMI) is limited. We aimed to investigate whether AG is a predictor of short-term and long-term all-cause mortality after AMI. PATIENTS AND
methodsWe examined 1806 patients diagnosed with AMI in intensive care unit from the Medical Information Mart for Intensive Care III (MIMIC-III) database. We analyzed the association of AG with 30-day, 180-day and 1-year all-cause mortality on a continuous scale and in categories, using multivariable Cox regression. We utilized restricted cubic splines to evaluate the linearity between hazard ratio (HR) and AG concentrations.
resultsAG was associated with a higher risk of 30-day, 180-day and 1-year all-cause mortality, with adjusted HRs of 1.083 (95% CI 1.051 to 1.117), 1.077 (95% CI 1.049 to 1.105), and 1.074 (95% CI 1.047 to 1.101), respectively. The results were consistent in subgroup analyses. The association between AG and all-cause mortality was linear for 180-day and 1-year mortality, and near linear for 30-day mortality, as higher concentrations were associated with high all-cause mortality. When stratified according to quartiles, AG was associated with 30-day mortality (HR[95% CI]: second quartile, 2.243[1.273, 3.955]; third quartile, 3.026[1.763, 5.194]; top quartile, 4.402[2.573, 7.531]), 180-day mortality (HR[95% CI]: second quartile, 1.719[1.118, 2.645]; third quartile, 2.362[1.575, 3.542]; top quartile, 3.116[2.077, 4.676]), and 1-year mortality (HR[95% CI]: second quartile, 1.700[1.143, 2.528]; third quartile, 2.239[1.536, 3.264]; top quartile, 2.876[1.969, 4.201]) using bottom quartile as reference.
conclusionWe firstly demonstrated that higher AG was significantly associated with increased 30-day, 180-day and 1-year all-cause mortality in AMI patients. AG as an easily obtained marker is of strong and reliable predictive value for AMI mortality during follow-up.
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