Evidence map›Paper›PMID 35023914›Full record

ReviewInternational journal of chronic obstructive pulmonary disease

Measuring Peak Inspiratory Flow in Patients with Chronic Obstructive Pulmonary Disease.

Jill A Ohar, Gary T Ferguson, Donald A Mahler, M Bradley Drummond, Rajiv Dhand, Roy A Pleasants, Antonio Anzueto, David M G Halpin, David B Price, Gail S Drescher and 4 more

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05292053 (Establishing Outcomes of Once-Daily ICS/LABA/LAMA Plus PRN Respiratory Therapy Treatments in Hospitalized Patients With COPD Exacerbations), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05292053 phase4completednot on this map

Establishing Outcomes of Once-Daily ICS/LABA/LAMA Plus PRN Respiratory Therapy Treatments in Hospitalized Patients With COPD Exacerbations (SUNDIAL-COPD)

TypeinterventionalSponsorBaylor Research InstituteRan2022 to 2025Enrolled80ConditionsCopdArmsTRELEGY ELLIPTA 100Mcg-62.5Mcg-25Mcg/Actuation Powder for Inhalation
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Respiratory Muscle Strength and Mortality in Patients with COPD: A Systematic Review and Meta-Analysis.International journal of chronic obstructive pulmonary disease · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 3 countries.

Jill A OharSection of Pulmonary, Critical Care, Allergy, and Immunology, School of Medicine, Wake Forest University, Winston-Salem, NC, USA.ORCID 0000-0002-2757-6806
Gary T FergusonPulmonary Research Institute of Southeast Michigan, Farmington Hills, MI, USA.
Donald A MahlerGeisel School of Medicine at Dartmouth, Hanover, NH, USA.ORCID 0000-0001-6332-4895
M Bradley DrummondDivision of Pulmonary Diseases and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-6968-4610
Rajiv DhandDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN, USA.ORCID 0000-0002-3621-2422
Roy A PleasantsDivision of Pulmonary Diseases and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Antonio AnzuetoPulmonology Section, University of Texas Health, and South Texas Veterans Health Care System, San Antonio, TX, USA.
David M G HalpinUniversity of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK.ORCID 0000-0003-2009-4406
David B PriceAcademic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.ORCID 0000-0002-9728-9992
Gail S DrescherPulmonary Services Department, MedStar Washington Hospital Center, Washington, DC, USA.
Haley M HoyTransplant Center, Vanderbilt University Medical Center, Nashville, TN, USA.
John HaughneyAcademic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.ORCID 0000-0002-6809-6964
Michael W HessCOPD Foundation, Kalamazoo, MI, USA.
Omar S UsmaniNational Heart and Lung Institute, Imperial College London and Royal Brompton Hospital, London, UK.ORCID 0000-0002-4367-254X
University of Aberdeen · GBUniversity of North Carolina at Chapel Hill · USCOPD Foundation · USDartmouth College · USMedStar Washington Hospital Center · USRoyal Brompton Hospital · GBThe University of Texas Health Science Center at San Antonio · USUniversity of Exeter · GBUniversity of Tennessee at Knoxville · USVanderbilt University Medical Center · USWake Forest University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dry powder inhalers (DPIs) are breath actuated, and patients using DPIs need to generate an optimal inspiratory flow during the inhalation maneuver for effective drug delivery to the lungs. However, practical and standardized recommendations for measuring peak inspiratory flow (PIF)-a potential indicator for effective DPI use in chronic obstructive pulmonary disease (COPD)-are lacking. To evaluate recommended PIF assessment approaches, we reviewed the Instructions for Use of the In-Check™ DIAL and the prescribing information for eight DPIs approved for use in the treatment of COPD in the United States. To evaluate applied PIF assessment approaches, we conducted a PubMed search from inception to August 31, 2021, for reports of clinical and real-life studies where PIF was measured using the In-Check™ DIAL or through a DPI in patients with COPD. Evaluation of collective sources, including 47 applicable studies, showed that instructions related to the positioning of the patient with their DPI, instructions for exhalation before the inhalation maneuver, the inhalation maneuver itself, and post-inhalation breath-hold times varied, and in many instances, appeared vague and/or incomplete. We observed considerable variation in how PIF was measured in clinical and real-life studies, underscoring the need for a standardized method of PIF measurement. Standardization of technique will facilitate comparisons among studies. Based on these findings and our clinical and research experience, we propose specific recommendations for PIF measurement to standardize the process and better ensure accurate and reliable PIF values in clinical trials and in daily clinical practice.

Indexed as

Pulmonary Disease, Chronic ObstructiveAdministration, InhalationDry Powder InhalersHumansLungchronic obstructive pulmonary diseasedry powder inhalerspeak inspiratory flow

Identifiers

PMID35023914
PMCPMC8747625
OpenAlexW3208482292

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.