Evidence map›Paper›PMID 35023911›Full record

ArticleInternational journal of chronic obstructive pulmonary disease

Predictors of Influenza PCR Positivity in Acute Exacerbations of Chronic Obstructive Pulmonary Disease.

Calvin You Jia Chen, Min Sen Yew, John Arputhan Abisheganaden, Huiying Xu

Abstract read
In one paragraph

Article in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Calvin You Jia ChenLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.ORCID 0000-0003-4220-9331
Min Sen YewDepartment of Cardiology, Tan Tock Seng Hospital, Singapore, Singapore.ORCID 0000-0002-1491-5864
John Arputhan AbisheganadenDepartment of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore, Singapore.
Huiying XuDepartment of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore, Singapore.ORCID 0000-0003-3956-9715

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeInfluenza infection is an important cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Clinical features predicting influenza PCR positivity are unknown. We aim to identify predictors of influenza PCR positivity in AECOPD. PATIENTS AND

methodsA retrospective study of AECOPD cases admitted between 1st January 2016 to 30 June 2017 with combined nasal/throat swabs sent for influenza PCR (Xpert Xpress Flu/RSV) within 24 hours of admission was performed. Clinical parameters and investigations within 24 hours of admission were retrieved from electronic medical records.

resultsInfluenza PCR were sent for 925 AECOPD cases (mean age 75 years, 87.9% male). There were 90 PCR positive cases (68 Influenza A, 22 Influenza B). Influenza PCR positive cases had higher temperatures, higher heart rates, lower white cell and lower eosinophil counts. Age, gender, COPD severity, comorbidities and smoking status were similar in both groups. There were no differences in blood pressure, oxygen status, neutrophil or lymphocyte counts, C reactive protein, procalcitonin or chest X-ray consolidation between groups. Higher temperature, higher heart rate, white cell count in the lowest quartile (Q1 < 8.1 x10

conclusionHigher temperature, higher heart rate, low white cell count (especially when < 8.1 x10

Indexed as

Influenza, HumanPulmonary Disease, Chronic ObstructiveAcute DiseaseAgedDisease ProgressionFemaleHumansLeukocyte CountMalePolymerase Chain ReactionRetrospective Studieschronic obstructive pulmonary diseaseeosinophilexacerbationinfluenza

Identifiers

PMID35023911
PMCPMC8747709

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.