Evidence map›Paper›PMID 35023891›Full record

ArticleHippokratia

Decreased diversity of salivary microbiome in patients with stable decompensated cirrhosis.

T Oikonomou, E Cholongitas, G Gioula, F Minti, A Melidou, E Protonotariou, E Akriviadis, I Goulis

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Hippokratia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

T OikonomouFourth Department of Internal Medicine, Hippokration General Hospital, Medical School of Aristotle University of Thessaloniki, Thessaloniki.
E CholongitasFirst Department of Internal Medicine, Laiko General Hospital, Medical School of National and Kapodistrian University of Athens, Athens.
G GioulaMicrobiology Department, Medical School of Aristotle University of Thessaloniki, Thessaloniki Greece.
F MintiMicrobiology Department, Medical School of Aristotle University of Thessaloniki, Thessaloniki Greece.
A MelidouMicrobiology Department, Medical School of Aristotle University of Thessaloniki, Thessaloniki Greece.
E ProtonotariouMicrobiology Department, Medical School of Aristotle University of Thessaloniki, Thessaloniki Greece.
E AkriviadisFourth Department of Internal Medicine, Hippokration General Hospital, Medical School of Aristotle University of Thessaloniki, Thessaloniki.
I GoulisFourth Department of Internal Medicine, Hippokration General Hospital, Medical School of Aristotle University of Thessaloniki, Thessaloniki.
Aristotle University of Thessaloniki · GRLaiko General Hospital of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the setting of the oral-gut-liver axis, microbiome dysbiosis has been associated with decompensated cirrhosis progression. However, little is known on salivary microbiome profiles in stable decompensated patients.

methodsWe studied patients with stable decompensated cirrhosis (n =28) and matched healthy controls (n =26). There were five patients (17.8 %) with hepatocellular carcinoma (HCC). Microbiomes of the 54 salivary samples were profiled through next-generation sequencing of the 16S-rRNA region in bacteria.

resultsThe two study groups (patients and controls) did not differ significantly concerning their baseline characteristics. The most abundant phyla were

conclusionsPatients with stable decompensated cirrhosis of various etiology and history of complications have decreased diversity of their salivary microbiome. PCoA and Boruta algorithm may represent useful tools to discriminate the salivary microbiome in patients with decompensation. Further studies are needed to establish the utility of salivary microbiome analysis, which is easier obtained than fecal, in decompensated cirrhosis. HIPPOKRATIA 2020, 24(4): 157-165.

Indexed as

bacterial diversityDecompensated cirrhosisdysbiosissalivary microbiome

Identifiers

PMID35023891
PMCPMC8747582
OpenAlexW4206889783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.