Evidence map›Paper›PMID 35023810›Full record

ArticleGut microbes

Identification of Gut Bacteria such as Lactobacillus johnsonii that Disseminate to Systemic Tissues of Wild Type and MyD88-/- Mice.

Sreeram Udayan, Panagiota Stamou, Fiona Crispie, Ana Hickey, Alexandria N Floyd, Chyi-Song Hsieh, Paul D Cotter, Orla O'Sullivan, Silvia Melgar, Paul W O'Toole and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Sreeram UdayanAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Panagiota StamouAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Fiona CrispieAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Ana HickeyAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Alexandria N FloydDepartment of Internal Medicine, Division of Gastroenterology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Chyi-Song HsiehDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, USA.
Paul D CotterAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID 0000-0002-5465-9068
Orla O'SullivanAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Silvia MelgarAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Paul W O'TooleAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID 0000-0001-5377-0824
Rodney D NewberryDepartment of Internal Medicine, Division of Gastroenterology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Valerio RossiniAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Ken NallyAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID 0000-0002-9833-170X
University College Cork · IEWashington University in St. Louis · USTeagasc - The Irish Agriculture and Food Development Authority · IE

Funding

GOBLET CELLS IN INTESTINAL IMMUNE HOMEOSTATSISR01DK097317 · NIDDK · WASHINGTON UNIVERSITY · PI NEWBERRY, RODNEY D · 2012 to 2025
$5.6M
Gut Intrinsic Inflammatory ResponsesU01AI163073 · NIAID · WASHINGTON UNIVERSITY · PI HSIEH, CHYI S, NEWBERRY, RODNEY D · 2021 to 2025
$2.6M
NIAID NIH HHS U01 AI163073NIDDK NIH HHS R01 DK097317
6 · The paper itself

Abstract

In healthy hosts the gut microbiota is restricted to gut tissues by several barriers some of which require MyD88-dependent innate immune sensor pathways. Nevertheless, some gut taxa have been reported to disseminate to systemic tissues. However, the extent to which this normally occurs during homeostasis in healthy organisms is still unknown. In this study, we recovered viable gut bacteria from systemic tissues of healthy wild type (WT) and MyD88

Indexed as

Gastrointestinal MicrobiomeAnimalsBacteriaBacterial Physiological PhenomenaDendritic CellsGastrointestinal TractLactobacillus johnsoniiMaleMiceMice, Inbred C57BLMice, KnockoutMyeloid Differentiation Factor 88Myd88 protein, mouseMyeloid Differentiation Factor 88commensal bacteriaGut microbiotaimmunomodulationLactobacillus johnsoniiMyD88symbiontssystemic disseminationtranslocation

Identifiers

PMID35023810
PMCPMC8765072
OpenAlexW4205761844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.