Evidence map›Paper›PMID 35023730›Full record

ArticleACS synthetic biology2022

GAMES: A Dynamic Model Development Workflow for Rigorous Characterization of Synthetic Genetic Systems.

Kate E Dray, Joseph J Muldoon, Niall M Mangan, Neda Bagheri, Joshua N Leonard

Erratum issuedAbstract read
In one paragraph

Article in ACS synthetic biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Kate E DrayDepartment of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0002-2972-047X
Joseph J MuldoonDepartment of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0003-3784-3565
Niall M ManganEngineering Sciences and Applied Mathematics Program, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0002-3491-8341
Neda BagheriDepartment of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0003-0146-4627
Joshua N LeonardDepartment of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0003-4359-6126

Funding

Design-driven engineering of robust mammalian sense-and-respond functions: from parts to programsR01EB026510 · NIBIB · NORTHWESTERN UNIVERSITY · PI Neda Bagheri, Joshua Nathaniel Leonard · 2018 to 2026
$3.7M
NIBIB NIH HHS R01 EB026510
6 · The paper itself

Abstract

Mathematical modeling is invaluable for advancing understanding and design of synthetic biological systems. However, the model development process is complicated and often unintuitive, requiring iteration on various computational tasks and comparisons with experimental data.

Indexed as

Models, BiologicalSystems BiologyHumansModels, TheoreticalResearch DesignWorkflowmathematical modelingODE model developmentparameter estimationparameter identifiabilitysynthetic biology

Identifiers

PMID35023730
PMCPMC9097825

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.