Evidence map›Paper›PMID 35023354›Full record

ArticleJournal of the American Heart Association2022

Ajmaline-Induced Abnormalities in Brugada Syndrome: Evaluation With ECG Imaging.

Luigi Pannone, Cinzia Monaco, Antonio Sorgente, Pasquale Vergara, Paul-Adrian Calburean, Anaïs Gauthey, Antonio Bisignani, Shuichiro Kazawa, Antanas Strazdas, Joerelle Mojica and 19 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. In vivo mapping of human polymorphic ventricular tachycardia.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Assessment of activation delay in the right ventricular outflow tract as a potential complementary diagnostic tool for Brugada Syndrome.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Patient-reported outcome measures on mental health and psychosocial factors in patients with Brugada syndrome.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  12. Genetic testing in children with Brugada syndrome: results from a large prospective registry.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  13. Heart rate variability and microvolt T wave alternans changes during ajmaline test may predict prognosis in Brugada syndrome.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023
    Article
  14. Evaluation of photogrammetry for medical application in cardiology.Frontiers in bioengineering and biotechnology · 2023
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 1 institution in 1 country.

Luigi PannoneHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.ORCID 0000-0001-9769-1511
Cinzia MonacoHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.
Antonio SorgenteHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.ORCID 0000-0002-0078-9393
Pasquale VergaraHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.ORCID 0000-0001-7751-6871
Paul-Adrian CalbureanHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.ORCID 0000-0002-4948-2587
Anaïs GautheyHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.
Antonio BisignaniHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.ORCID 0000-0003-3938-4948
Shuichiro KazawaHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.
Antanas StrazdasHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.
Joerelle MojicaHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.
Felicia LipartitiHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.
Maysam Al HousariHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.
Vincenzo MiragliaHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.
Sergio RizziHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.
Dimitrios SofianosHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.ORCID 0000-0002-9915-9665
Federico CecchiniHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.
Thiago Guimarães OsórioHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.ORCID 0000-0002-8883-9390
Gaetano PaparellaHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.
Robbert RamakHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.
Ingrid OvereinderHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.
Gezim BalaHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.
Alexandre AlmoradHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.
Erwin StrökerHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.
Gudrun PappaertHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.
Juan SieiraHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.
Pedro BrugadaHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.ORCID 0000-0003-3172-6106
Mark La MeirCardiac Surgery Department Universitair Ziekenhuis Brussel - Vrije Universiteit Brussel Brussels Belgium.
Gian-Battista ChierchiaHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.
Carlo de AsmundisHeart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and PacingUniversitair Ziekenhuis Brussel - Vrije Universiteit BrusselEuropean Reference Networks Guard-Heart Brussels Belgium.ORCID 0000-0001-9351-0760
Vrije Universiteit Brussel · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background The rate of sudden cardiac death (SCD) in Brugada syndrome (BrS) is ≈1%/y. Noninvasive electrocardiographic imaging is a noninvasive mapping system that has a role in assessing BrS depolarization and repolarization abnormalities. This study aimed to analyze electrocardiographic imaging parameters during ajmaline test (AJT). Methods and Results All consecutive epicardial maps of the right ventricle outflow tract (RVOT-EPI) in BrS with CardioInsight were retrospectively analyzed. (1) RVOT-EPI activation time (RVOT-AT); (2) RVOT-EPI recovery time, and (3) RVOT-EPI activation-recovery interval (RVOT-ARI) were calculated. ∆RVOT-AT, ∆RVOT-EPI recovery time, and ∆RVOT-ARI were defined as the difference in parameters before and after AJT. SCD-BrS patients were defined as individuals presenting a history of aborted SCD. Thirty-nine patients with BrS were retrospectively analyzed and 12 patients (30.8%) were SCD-BrS. After AJT, an increase in both RVOT-AT [105.9 milliseconds versus 65.8 milliseconds,

Indexed as

Brugada SyndromeAjmalineDeath, Sudden, CardiacElectrocardiographyHeart RateHumansRetrospective StudiesAjmalineBrugada syndromeECG imagingsudden cardiac death

Identifiers

PMID35023354
PMCPMC9238512
OpenAlexW4205903227

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.