ArticleJournal of the American Heart Association2022
Atrial Fibrillation and Stroke Symptoms in the REGARDS Study.
Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Predicting Incident Atrial Fibrillation after Stroke: A Scoping Review of Clinical Scores, Biomarkers, and AI-Enhanced Strategies.Cerebrovascular diseases extra · 2026Article
- Characterizing TIA and stroke symptomatology in a population-based study: implications for and diagnostic value of FAST-based public education.BMC public health · 2024Article
- Machine learning-based model to predict composite thromboembolic events among Chinese elderly patients with atrial fibrillation.BMC cardiovascular disorders · 2024Article
- Article
- Exploring the shared biomarkers between cardioembolic stroke and atrial fibrillation by WGCNA and machine learning.Frontiers in cardiovascular medicine · 2024Article
- Discovery ofBiology · 2023Article
- Racial, ethnic, and sex disparities in atrial fibrillation management: rate and rhythm control.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2023Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Background It is unknown if stroke symptoms in the absence of a stroke diagnosis are a sign of subtle cardioembolic phenomena. The objective of this study was to examine associations between atrial fibrillation (AF) and stroke symptoms among adults with no clinical history of stroke or transient ischemic attack (TIA). Methods and Results We evaluated associations between AF and self-reported stroke symptoms in the national, prospective REGARDS (Reasons for Geographic and Racial Differences in Stroke) cohort. We conducted cross-sectional (n=27 135) and longitudinal (n=21 932) analyses over 8 years of follow-up of REGARDS participants without stroke/transient ischemic attack and stratified by anticoagulant or antiplatelet agent use. The mean age was 64.4 (SD±9.4) years, 55.3% were women, and 40.8% were Black participants; 28.6% of participants with AF reported stroke symptoms. In the cross-sectional analysis, comparing participants with and without AF, the risk of stroke symptoms was elevated for adults with AF taking neither anticoagulants nor antiplatelet agents (odds ratio [OR], 2.22; 95% CI, 1.89-2.59) or antiplatelet agents only (OR, 1.92; 95% CI, 1.61-2.29) but not for adults with AF taking anticoagulants (OR, 1.08; 95% CI, 0.71-1.65). In the longitudinal analysis, the risk of stroke symptoms was also elevated for adults with AF taking neither anticoagulants nor antiplatelet agents (hazard ratio [HR], 1.41; 95% CI, 1.21-1.66) or antiplatelet agents only (HR, 1.23; 95% CI, 1.04-1.46) but not for adults with AF taking anticoagulants (HR, 0.86; 95% CI, 0.62-1.18). Conclusions Stroke symptoms in the absence of a stroke diagnosis may represent subclinical cardioembolic phenomena or "whispering strokes." Future studies examining the benefit of stroke symptom screening may be warranted.
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