ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022
Endothelial Retargeting of AAV9 In Vivo.
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Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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0cells of the map it votes in
26citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
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Who cites it
26 citing papers in PubMed, 32 citations in OpenAlex.
- Activating a patient-relevant pathogenic variant of a genetically defined heart disease in a humanized pig model.Lab animal · 2026Article
- Age-associated loss of lymphatic vessels promotes cardiac inflammation.Nature cardiovascular research · 2026Article
- Attenuating AAV-triggered innate immunity in the adult mouse nervous systemActa pharmaceutica Sinica. B · 2026Article
- Aortic asprosin overexpression does not ameliorate disease pathophysiology in a murine model of Marfan syndrome.Scientific reports · 2026Article
- Algorithm-based quantification of tissue vascularization in immunohistochemical stainings of tissue sections.Scientific reports · 2026Article
- Endothelial ZBTB16: a molecular shield against cardiac aging.European heart journal · 2026Article
- Advances in endothelial cell targeting by AAV vectors.Acta biochimica Polonica · 2026Review
- Correction of VWF multimerization in type 2A/IIC von Willebrand disease by exogenous VWF propeptide supplementation.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Long Non-coding RNA Based Therapy for Cardiovascular Disease.Journal of cardiovascular translational research · 2025Review
- PET-based tracking of CAR T cells and viral gene transfer using a cell surface reporter that binds to lanthanide complexes.Nature biomedical engineering · 2025Article
- Immunoregulatory Endothelial Cells Interact With T Cells After Myocardial Infarction.Circulation research · 2025Article
- Unraveling Etiological Indications and Therapeutic Implications of Familial Cerebral Cavernous Malformations in the Dawn of Gene Therapy for Monogenic Conditions.Current gene therapy · 2025Article
- Accelerated Endosomal Escape of Splice-Switching Oligonucleotides Enables Efficient Hepatic Splice Correction.ACS applied materials & interfaces · 2025Article
- Heterogeneity of Renal Endothelial Cells, Interact with Neighboring Cells, and Endothelial Injury in Chronic Kidney Disease: Mechanisms and Therapeutic Implications.International journal of medical sciences · 2025Review
- Inhibition of endothelial-to-mesenchymal transition in a large animal preclinical arteriovenous fistula model leads to improved remodelling and reduced stenosis.Cardiovascular research · 2024Article
- Regnase-1 overexpression as a therapeutic approach of Marfan syndrome.Molecular therapy. Methods & clinical development · 2024Article
- Navigating toward gene therapy in Marfan syndrome: A hope for halting aortic aneurysm.Molecular therapy. Methods & clinical development · 2024Article
- Gene therapy for the heart: encapsulated viruses to the rescue.Extracellular vesicles and circulating nucleic acids · 2024Article
- Extracellular Vesicle-Encapsulated Adeno-Associated Viruses for Therapeutic Gene Delivery to the Heart.Circulation · 2023Article
- Targeting and delivery of microRNA-targeting antisense oligonucleotides in cardiovascular diseases.Atherosclerosis · 2023Review
Corrections and comments
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Authors and funding
28 authors at 7 institutions in 2 countries.
Tarik BozogluKlinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
Seungmin LeeKlinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
Tilman ZieglerKlinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.ORCID 0000-0003-2291-5861
Victoria JurischKlinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
Sanne MaasDZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Andrea BaehrKlinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.ORCID 0000-0001-8075-8222
Rabea HinkelKlinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.ORCID 0000-0002-2936-0400
Amelie HoenigKlinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
Anjana HariharanKlinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
Christina Inyeop KimKlinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
Simon DeckerFaculty of Life Sciences, Department of Pharmaceutical Sciences, Laboratory of MacroMolecular Cancer Therapeutics (MMCT), University of Vienna, Althanstrasse 14, Vienna, 1090, Austria.
Haider SamiFaculty of Life Sciences, Department of Pharmaceutical Sciences, Laboratory of MacroMolecular Cancer Therapeutics (MMCT), University of Vienna, Althanstrasse 14, Vienna, 1090, Austria.
Tobias KopparaKlinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
Ruppert OellingerInstitute of Molecular Oncology and Functional Genomics, University Clinic rechts der Isar, Technical University of Munic, Germany.
Oliver J MüllerKlinik für Innere Medizin III and DZHK (German Center for Cardiovascular Research), partner site Hamburg, Kiel, Lübeck., UKSH, Kiel, Germany.
Derk FrankKlinik für Innere Medizin III and DZHK (German Center for Cardiovascular Research), partner site Hamburg, Kiel, Lübeck., UKSH, Kiel, Germany.
Remco MegensInstitute for Cardiovascular Prevention, Ludwigs-Maximilians-University, Munich, Germany.
Peter NelsonMedizinische Klinik und Poliklinik IV, Poliklinik Innenstadt, Ludwigs-Maximilians-University, Munich, Germany.
Christian WeberDZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Angelika SchniekeDepartment of Animal Sciences, Chair of Livestock Biotechnology, School of Life Sciences Weihenstephan, Technical University Munich, Germany.
Markus SperandioWalter Brendel Centre of Experimental Medicine and Institute of Cardiovascular Physiology and Pathophysiology, BioMedical Centre, Ludwig Maximilians University of Munich, Germany.
Gianluca SantamariaKlinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
Roland RadInstitute of Molecular Oncology and Functional Genomics, University Clinic rechts der Isar, Technical University of Munic, Germany.
Alessandra MorettiKlinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.ORCID 0000-0001-5782-7832
Karl-Ludwig LaugwitzKlinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
Oliver SoehnleinDZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Manfred OgrisFaculty of Life Sciences, Department of Pharmaceutical Sciences, Laboratory of MacroMolecular Cancer Therapeutics (MMCT), University of Vienna, Althanstrasse 14, Vienna, 1090, Austria.
Christian KupattKlinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.ORCID 0000-0002-3611-1218
TUM Klinikum · DEGerman Centre for Cardiovascular Research · DEUniversity of Vienna · ATLudwig-Maximilians-Universität München · DEGerman Primate Center · DEKlinik und Poliklinik für Orthopädie, Physikalische Medizin und Rehabilitation · DETechnical University of Munich · DE
Funding
DZHK Large animal platformEuropean Research CouncilGerman Ministry for Education and Research 01GU1105AGerman Research FoundationGerman Research Foundation INST 409/150-1German Research Foundation SFB1123-A1German Research Foundation SFB-TRR127-A2German Research Foundation SFB-TRR 267-B8
Abstract
Adeno-associated viruses (AAVs) are frequently used for gene transfer and gene editing in vivo, except for endothelial cells, which are remarkably resistant to unmodified AAV-transduction. AAVs are retargeted here toward endothelial cells by coating with second-generation polyamidoamine dendrimers (G2) linked to endothelial-affine peptides (CNN). G2
Indexed as
DependovirusEndothelial CellsAnimalsBlood PressureMiceMice, TransgenicRNA, Guide, CRISPR-Cas SystemsSwineRNA, Guide, CRISPR-Cas Systemsendotheliumsubject terms: gene therapyvascular biology
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.