ReviewWIREs mechanisms of disease2022
Seven challenges in the multiscale modeling of multicellular tissues.
Review in WIREs mechanisms of disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Process bigraphs and the architecture of compositional systems biology.PLoS computational biology · 2026Article
- AutomataGPT: Transformer-Based Forecasting and Ruleset Inference for Two-Dimensional Cellular Automata.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Virtual cell: Current perspectives and future prospects.The Journal of international medical research · 2026Review
- Multi-Scale Modeling and Experimental Validation of Thermo-Mechanical Responses in Femtosecond Laser Micromachining of Copper.Materials (Basel, Switzerland) · 2026Article
- Physical models of embryonic epithelial healing.PLoS computational biology · 2026Review
- Spatially structured models of viral dynamics: a scoping review.Microbiology and molecular biology reviews : MMBR · 2025Article
- AI-driven virtual cell models in preclinical research: technical pathways, validation mechanisms, and clinical translation potential.NPJ digital medicine · 2025Review
- The Mechanics of Building Functional Organs.Cold Spring Harbor perspectives in biology · 2025Review
- Analysis of systemic effects of dioxin on human health through template-and-anchor modeling.PLoS computational biology · 2025Article
- Foundations of a Compositional Systems Biology.ArXiv · 2024Article
- Multiscale modelling of transport in polymer-based reverse-osmosis/nanofiltration membranes: present and future.Discover nano · 2024Review
- Review
- Synthetic living materials in cancer biology.Nature reviews bioengineering · 2023Article
- FitMultiCell: simulating and parameterizing computational models of multi-scale and multi-cellular processes.Bioinformatics (Oxford, England) · 2023Article
- Generative models of morphogenesis in developmental biology.Seminars in cell & developmental biology · 2023Review
- From cells to form: A roadmap to study shape emergence in vivo.Biophysical journal · 2023Review
- BMX: Biological modelling and interface exchange.Scientific reports · 2023Article
- Article
- Concentration-Dependent Domain Evolution in Reaction-Diffusion Systems.Bulletin of mathematical biology · 2023Article
- What's next for computational systems biology?Frontiers in systems biology · 2023Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The growth and dynamics of multicellular tissues involve tightly regulated and coordinated morphogenetic cell behaviors, such as shape changes, movement, and division, which are governed by subcellular machinery and involve coupling through short- and long-range signals. A key challenge in the fields of developmental biology, tissue engineering and regenerative medicine is to understand how relationships between scales produce emergent tissue-scale behaviors. Recent advances in molecular biology, live-imaging and ex vivo techniques have revolutionized our ability to study these processes experimentally. To fully leverage these techniques and obtain a more comprehensive understanding of the causal relationships underlying tissue dynamics, computational modeling approaches are increasingly spanning multiple spatial and temporal scales, and are coupling cell shape, growth, mechanics, and signaling. Yet such models remain challenging: modeling at each scale requires different areas of technical skills, while integration across scales necessitates the solution to novel mathematical and computational problems. This review aims to summarize recent progress in multiscale modeling of multicellular tissues and to highlight ongoing challenges associated with the construction, implementation, interrogation, and validation of such models. This article is categorized under: Reproductive System Diseases > Computational Models Metabolic Diseases > Computational Models Cancer > Computational Models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.