Evidence map›Paper›PMID 35023255›Full record

ArticleHuman brain mapping2022

Automatic brain segmentation in preterm infants with post-hemorrhagic hydrocephalus using 3D Bayesian U-Net.

Axel Largent, Josepheen De Asis-Cruz, Kushal Kapse, Scott D Barnett, Jonathan Murnick, Sudeepta Basu, Nicole Andersen, Stephanie Norman, Nickie Andescavage, Catherine Limperopoulos

Open access · goldAbstract read
In one paragraph

Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Axel LargentDeveloping Brain Institute, Department of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, District of Columbia, USA.ORCID 0000-0003-0336-6350
Josepheen De Asis-CruzDeveloping Brain Institute, Department of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, District of Columbia, USA.
Kushal KapseDeveloping Brain Institute, Department of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, District of Columbia, USA.
Scott D BarnettDeveloping Brain Institute, Department of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, District of Columbia, USA.
Jonathan MurnickDeveloping Brain Institute, Department of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, District of Columbia, USA.
Sudeepta BasuDeveloping Brain Institute, Department of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, District of Columbia, USA.
Nicole AndersenDeveloping Brain Institute, Department of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, District of Columbia, USA.
Stephanie NormanDeveloping Brain Institute, Department of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, District of Columbia, USA.
Nickie AndescavageDeveloping Brain Institute, Department of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, District of Columbia, USA.
Catherine LimperopoulosDeveloping Brain Institute, Department of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, District of Columbia, USA.
Children's National · USGeorge Washington University Hospital · US

Funding

Neurobehavioral Evaluation CoreP50HD105328 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI WILLIAM Davis GAILLARD · 2021 to 2026
$9.3M
Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VITTORIO GALLO, VITTORIO GALLO VITTORIO GALLO · 2016 to 2020
$5.9M
NICHD NIH HHS P50 HD105328NICHD NIH HHS U54 HD090257
6 · The paper itself

Abstract

Post-hemorrhagic hydrocephalus (PHH) is a severe complication of intraventricular hemorrhage (IVH) in very preterm infants. PHH monitoring and treatment decisions rely heavily on manual and subjective two-dimensional measurements of the ventricles. Automatic and reliable three-dimensional (3D) measurements of the ventricles may provide a more accurate assessment of PHH, and lead to improved monitoring and treatment decisions. To accurately and efficiently obtain these 3D measurements, automatic segmentation of the ventricles can be explored. However, this segmentation is challenging due to the large ventricular anatomical shape variability in preterm infants diagnosed with PHH. This study aims to (a) propose a Bayesian U-Net method using 3D spatial concrete dropout for automatic brain segmentation (with uncertainty assessment) of preterm infants with PHH; and (b) compare the Bayesian method to three reference methods: DenseNet, U-Net, and ensemble learning using DenseNets and U-Nets. A total of 41 T

Indexed as

HydrocephalusInfant, PrematureBayes TheoremCerebral HemorrhageCerebral VentriclesHumansInfantInfant, Newbornautomatic brain segmentationBayesian deep learningMonte Carlo dropoutpost-hemorrhagic hydrocephaluspreterm infantsuncertainty assessment

Identifiers

PMID35023255
PMCPMC8933325
OpenAlexW4206205575

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.