ArticleAdvances in experimental medicine and biology2021
Skin Mirrors Brain: A Chance for Alzheimer's Disease Research.
Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 7 citations in OpenAlex.
- GRWD1 as a Novel Signature and It Down Regulates IFN in Skin Aging.Cell biochemistry and function · 2026Article
- Cell Cycle Dysfunction and Metabolic Alterations Consistent With Pathological Tau in Progressive Supranuclear Palsy Derived Fibroblasts.Molecular neurobiology · 2026Article
- Cell and tissue reprogramming: Unlocking a new era in medical drug discovery.Pharmacological reviews · 2025Review
- Modeling Alzheimer's Disease: A Review of Gene-Modified and Induced Animal Models, Complex Cell Culture Models, and Computational Modeling.Brain sciences · 2025Review
- Gene Therapy for Skin Aging.Current gene therapy · 2025Review
- Skin-brain axis in Alzheimer's disease - Pathologic, diagnostic, and therapeutic implications: A Hypothetical Review.Aging and disease · 2024Review
- Advances in Amyloid-β Clearance in the Brain and Periphery: Implications for Neurodegenerative Diseases.Experimental neurobiology · 2023Review
- Exploring the Skin Brain Link: Biomarkers in the Skin with Implications for Aging Research and Alzheimer's Disease Diagnostics.International journal of molecular sciences · 2023Article
- Distribution of α-Synuclein Aggregation in the Peripheral Tissues.Neurochemical research · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The accessibility of skin and the easy isolation of its cells and matrix components provide a valuable tool for studying the molecular factors involved in human aging. Moreover, increasing evidence corroborates the use of the skin as a model for age-associated pathological conditions in the entire body. Apparently based on the fact that the nervous system and skin share a common ectodermal origin, certain genes and molecular pathways associated with the pathomechanism of neurodegenerative diseases modify their expression with progressing skin aging. Alzheimer's disease and intrinsic skin aging share a common signalling pathway with major genes been regulated in both tissues. In our studies, functional neuronal cells derived from induced pluripotent stem cells originating from normal human skin fibroblasts of patients with sporadic Alzheimer's disease expressed proteins, which are implicated in Alzheimer's disease pathophysiology. Cumulative data lead to valuable insights regarding the understanding of Alzheimer's disease and its pathogenesis, given that these innovative patient cell models display the Alzheimer's disease phenotype.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.