ArticleAdvances in experimental medicine and biology2021
The Role of Inflammatory Biomarkers as a Diagnostic Tool for Possible Late-Life Cognitive Decline and Dementias.
Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Analysis and interpretation of inflammatory fluid markers in Alzheimer's disease: a roadmap for standardization.Journal of neuroinflammation · 2025Review
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4 authors.
Funding
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Abstract
The objective of this paper was to explore whether inflammatory biomarkers, especially C-reactive protein (CRP) and high-sensitivity CRP (hsCRP), can be used as a diagnostic tool for possible late-life cognitive decline and dementias. Twelve studies were identified since 2010 involving 13,174 subjects, and one study recruited only healthy population. Inflammatory biomarkers CRP and hsCRP were obtained from blood plasma. Cognitive function was measured using the Mini-Mental State Examination (MMSE) as a basic test in 11 studies. Results were conflicted, five studies revealed no significant differences between higher CRP levels and cognitive decline, four studies demonstrated significant association even in healthy population, and three studies showed significant correlation of lower CRP levels to cognitive deficits. Inflammatory reaction is possibly associated with the pathogenesis of some cognitive impairment and dementias; however, as the results were conflicted, further research should be made, including the normal aging factor, both in healthy and in demented or cognitive declined population.
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