Evidence map›Paper›PMID 35023030›Full record

ArticleClinical & experimental metastasis2022

Comparative associations of baseline frailty status and age with postoperative mortality and duration of hospital stay following metastatic brain tumor resection.

Alis J Dicpinigaitis, Simon Hanft, Jared B Cooper, Chirag D Gandhi, Syed Faraz Kazim, Meic H Schmidt, Fawaz Al-Mufti, Christian A Bowers

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In one paragraph

Article in Clinical & experimental metastasis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Alis J DicpinigaitisSchool of Medicine, New York Medical College, Valhalla, NY, 10595, USA.ORCID 0000-0001-8625-4949
Simon HanftDepartment of Neurosurgery, Westchester Medical Center at New York Medical College, Valhalla, NY, 10595, USA.
Jared B CooperDepartment of Neurosurgery, Westchester Medical Center at New York Medical College, Valhalla, NY, 10595, USA.
Chirag D GandhiDepartment of Neurosurgery, Westchester Medical Center at New York Medical College, Valhalla, NY, 10595, USA.
Syed Faraz KazimDepartment of Neurosurgery MSC10 5615, University of New Mexico Health Science Center, 1 University of New Mexico, Albuquerque, NM, 87106, USA.
Meic H SchmidtDepartment of Neurosurgery MSC10 5615, University of New Mexico Health Science Center, 1 University of New Mexico, Albuquerque, NM, 87106, USA.
Fawaz Al-MuftiDepartment of Neurosurgery, Westchester Medical Center at New York Medical College, Valhalla, NY, 10595, USA.
Christian A BowersDepartment of Neurosurgery MSC10 5615, University of New Mexico Health Science Center, 1 University of New Mexico, Albuquerque, NM, 87106, USA. CABowers@salud.unm.edu.
Westchester Medical Center · USUniversity of New Mexico · USNew York Medical College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastatic brain tumors are the most common intracranial neoplasms diagnosed in the United States. Although baseline frailty status has been validated as a robust predictor of morbidity and mortality across various surgical disciplines, evidence within cranial neurosurgical oncology is limited. Adult metastatic brain tumor patients treated with resection were identified in the National Inpatient Sample during the period of 2015-2018. Frailty was quantified using the 11-point modified frailty index (mFI-11) and its association with clinical endpoints was evaluated through complex samples multivariable logistic regression and receiver operating characteristic (ROC) curve analyses. Among 13,650 metastatic brain tumor patients identified (mean age 62.8 years), 26.8% (n = 3665) were robust (mFI = 0), 31.4% (n = 4660) were pre-frail (mFI = 1), 23.2% (n = 3165) were frail (mFI = 2), and 15.8% (n = 2160) were severely frail (mFI ≥ 3). On univariable assessment, these cohorts stratified by increasing frailty were significantly associated with postoperative complications (13.6%, 15.9%, 23.9%, 26.4%; p < 0.001), mortality (1.2%, 1.4%, 2.7%, 3.2%; p = 0.028), and extended length of stay (eLOS) (15.7%, 22.5%, 28.9%, 37.7%; p < 0.001). Following multivariable logistic regression analysis, frailty (by mFI-11) was independently associated with postoperative mortality (aOR 1.34, 95% CI 1.08, 1.65) and eLOS (aOR 1.26, 95% CI 1.17, 1.37), while increasing age was not associated with these endpoints. ROC curve analysis demonstrated superior discrimination of frailty (by mFI-11) in comparison with age for both mortality (AUC 0.61 vs. 0.58) and eLOS (AUC 0.61 vs. 0.53). Further statistical assessment through propensity score adjustment and decision tree analysis confirmed and extended the findings of the primary analytical models. Frailty may be a more robust predictor of postoperative outcomes in comparison with age following metastatic brain tumor resection.

Indexed as

Brain NeoplasmsFrailtyAdultHumansLength of StayMiddle AgedPostoperative ComplicationsRetrospective StudiesRisk AssessmentRisk FactorsUnited StatesCraniotomyDatabaseFrailtyMetastatic brain tumor

Identifiers

PMID35023030
OpenAlexW4205904802

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.